[{"@graph": [{"@id": "https://v25.proteinatlas.org/humanproteome/cell+line", "@type": ["http://schema.org/DataSet"], "http://schema.org/creator": [{"@id": "_:Nf3573309491745daa7872c90f497ed52"}, {"@id": "_:Ne5cebe32fb804c35b6e8e53fea5c25ad"}], "http://schema.org/description": [{"@value": "\t\n\t\tCell line methods\n\t\t\n\t\t\t\n\t\t\n\t\n\tThe Cell line resource contains information on genome-wide RNA expression profiles of human protein-coding genes in 1206  human cell lines, including 1132 cancer cell lines. The transcriptomics analysis includes classification based on specificity analysis across 28 cancer types, distribution and expression cluster analysis across all cell lines and for selected cancer types also analysis of similarity of the cell lines to their corresponding cancer type. More information about the specific content and the generation and analysis of the data in the resource can be found in the Methods summary.\nLearn about:\n\nif a gene is enriched in cellines from a particular cancer type (specificity)\nwhich genes have a similar expression profile across the cell lines (expression cluster)\nthe catalogue of genes elevated in each of the cell lines\nwhich cell line has the most consistent expression profile to its corresponding TCGA disease cohort (i.e., the best cell lines for cancer study)\ncancer-related pathway and cytokine activity of each cell line\n"}], "http://schema.org/license": [{"@id": "https://www.proteinatlas.org/about/licence"}], "http://schema.org/name": [{"@value": "Human Protein Atlas - Cell line"}]}, {"@id": "_:Nf3573309491745daa7872c90f497ed52", "@type": ["http://schema.org/Organization"], "http://schema.org/email": [{"@value": "contact@proteinatlas.org"}], "http://schema.org/founder": [{"@id": "_:N5e11e6ee231144478a7e3204a87ff289"}], "http://schema.org/logo": [{"@id": "https://www.proteinatlas.org/images_static/logo.gif"}], "http://schema.org/name": [{"@value": "Human Protein Atlas"}]}, {"@id": "_:N5e11e6ee231144478a7e3204a87ff289", "@type": ["http://schema.org/Person"], "http://schema.org/familyName": [{"@value": "Uhlen"}], "http://schema.org/givenName": [{"@value": "Mathias"}], "http://schema.org/identifier": [{"@value": "orcid.org/0000-0002-4858-8056"}]}, {"@id": "_:Ne5cebe32fb804c35b6e8e53fea5c25ad", "@type": ["http://schema.org/Organization"], "http://schema.org/email": [{"@value": "contact@proteinatlas.org"}], "http://schema.org/founder": [{"@id": "_:N27b403e127ef4b258ac42aec7a07deb6"}], "http://schema.org/logo": [{"@id": "https://www.proteinatlas.org/images_static/logo.gif"}], "http://schema.org/name": [{"@value": "Human Protein Atlas"}]}, {"@id": "_:N27b403e127ef4b258ac42aec7a07deb6", "@type": ["http://schema.org/Person"], "http://schema.org/familyName": [{"@value": "Uhlen"}], "http://schema.org/givenName": [{"@value": "Mathias"}], "http://schema.org/identifier": [{"@value": "orcid.org/0000-0002-4858-8056"}]}, {"@id": "https://v25.proteinatlas.org/humanproteome/tissue", "@type": ["http://schema.org/DataSet"], "http://schema.org/creator": [{"@id": "_:Ndb990627ec514d389e446c5dacd72831"}, {"@id": "_:N33c78b63e17c42109f126c799f551e6a"}], "http://schema.org/description": [{"@value": "\t\n\t\tTissue methods\n\t\t\n\t\t\t\n\t\t\n\t\n\tThis resource of the Human Protein Atlas focuses on the expression profiles in human tissues of genes both on the mRNA and protein level. The protein expression data from 45 normal human tissue types is derived from antibody-based protein profiling using conventional and multiplex immunohistochemistry. All underlying images of immunohistochemistry stained normal tissues are available together with knowledge-based annotation of protein expression levels. The protein data covers 15312 genes (76%) for which there are available antibodies. The mRNA expression data is derived from deep sequencing of RNA (RNA-seq) from 51 different normal tissue types. \nMore information about the specific content and the generation and analysis of the data in the resource can be found on the Methods Summary.\nLearn about:\n\nprotein localization in tissues at a single-cell level \nif a gene is enriched in a particular tissue (specificity)\nwhich genes have a similar expression profile across tissues (expression cluster) \n"}], "http://schema.org/license": [{"@id": "https://www.proteinatlas.org/about/licence"}], "http://schema.org/name": [{"@value": "Human Protein Atlas - Tissue"}]}, {"@id": "_:Ndb990627ec514d389e446c5dacd72831", "@type": ["http://schema.org/Organization"], "http://schema.org/email": [{"@value": "contact@proteinatlas.org"}], "http://schema.org/founder": [{"@id": "_:Nefbea762a9d34738956226525cace470"}], "http://schema.org/logo": [{"@id": "https://www.proteinatlas.org/images_static/logo.gif"}], "http://schema.org/name": [{"@value": "Human Protein Atlas"}]}, {"@id": "_:Nefbea762a9d34738956226525cace470", "@type": ["http://schema.org/Person"], "http://schema.org/familyName": [{"@value": "Uhlen"}], "http://schema.org/givenName": [{"@value": "Mathias"}], "http://schema.org/identifier": [{"@value": "orcid.org/0000-0002-4858-8056"}]}, {"@id": "_:N33c78b63e17c42109f126c799f551e6a", "@type": ["http://schema.org/Organization"], "http://schema.org/email": [{"@value": "contact@proteinatlas.org"}], "http://schema.org/founder": [{"@id": "_:Nb86b431dbbd44238a95e56992066d572"}], "http://schema.org/logo": [{"@id": "https://www.proteinatlas.org/images_static/logo.gif"}], "http://schema.org/name": [{"@value": "Human Protein Atlas"}]}, {"@id": "_:Nb86b431dbbd44238a95e56992066d572", "@type": ["http://schema.org/Person"], "http://schema.org/familyName": [{"@value": "Uhlen"}], "http://schema.org/givenName": [{"@value": "Mathias"}], "http://schema.org/identifier": [{"@value": "orcid.org/0000-0002-4858-8056"}]}, {"@id": "https://v25.proteinatlas.org/humanproteome/brain", "@type": ["http://schema.org/DataSet"], "http://schema.org/creator": [{"@id": "_:N6b8a770ecccb4338967884d18848e07e"}, {"@id": "_:N0dec0e09de8c474fbf98265505594dc3"}], "http://schema.org/description": [{"@value": "\t\n\t\tBrain methods\n\t\t\n\t\t\t\n\t\t\n\t\n\tThis resource provides comprehensive spatial profiling of the Brain, including overview of protein expression in the mammalian brain based on integration of data from human, pig and mouse. Transcriptomics data combined with affinity-based protein in situ localization down to single cell detail is available in this brain-centric sub atlas of the Human Protein Atlas. The data presented are for human genes and their one-to-one orthologues in pig and mouse. Gene summary pages provide the hierarchical expression landscape form 13 main regions of the brain to individual nuclei and subfields for every protein coding gene. For selected proteins, high content images are available to explore the cellular and subcellular protein distribution. In addition, the Brain resource contains lists of genes with elevated expression in one or a group of regions to help the user identify unique protein expression profiles linked to physiology and function. \nMore information about the specific content and the generation and analysis of the data in this resource can be found on the Methods Summary.\nLearn about:\n\nExpression levels for all human proteins in regions and subregions of the human brain\nExpression levels for all proteins with human orthologs in regions and subregions of the pig and mouse brain\nBrain enriched genes with higher expression in any of the regions of the brain compared to peripheral organs\nRegional enriched genes with higher expression in a single or few regions of the brain\nCell-type and cell-compartment distribution of selected proteins in the human and mouse brain\nDifferences in gene expression between mammalian species\n\nAdditional information:\nIn addition to the data provided in the brain resource there is also data on human retina and single cell data containing information on protein expression in human neuronal and non-neuronal cell-types in the central nervous system. "}], "http://schema.org/license": [{"@id": "https://www.proteinatlas.org/about/licence"}], "http://schema.org/name": [{"@value": "Human Protein Atlas - Brain"}]}, {"@id": "_:N6b8a770ecccb4338967884d18848e07e", "@type": ["http://schema.org/Organization"], "http://schema.org/email": [{"@value": "contact@proteinatlas.org"}], "http://schema.org/founder": [{"@id": "_:N56bc8db8744341618cf502e93d34434c"}], "http://schema.org/logo": [{"@id": "https://www.proteinatlas.org/images_static/logo.gif"}], "http://schema.org/name": [{"@value": "Human Protein Atlas"}]}, {"@id": "_:N56bc8db8744341618cf502e93d34434c", "@type": ["http://schema.org/Person"], "http://schema.org/familyName": [{"@value": "Uhlen"}], "http://schema.org/givenName": [{"@value": "Mathias"}], "http://schema.org/identifier": [{"@value": "orcid.org/0000-0002-4858-8056"}]}, {"@id": "_:N0dec0e09de8c474fbf98265505594dc3", "@type": ["http://schema.org/Organization"], "http://schema.org/email": [{"@value": "contact@proteinatlas.org"}], "http://schema.org/founder": [{"@id": "_:Na13829d04e55429fb5cedef819b6636d"}], "http://schema.org/logo": [{"@id": "https://www.proteinatlas.org/images_static/logo.gif"}], "http://schema.org/name": [{"@value": "Human Protein Atlas"}]}, {"@id": "_:Na13829d04e55429fb5cedef819b6636d", "@type": ["http://schema.org/Person"], "http://schema.org/familyName": [{"@value": "Uhlen"}], "http://schema.org/givenName": [{"@value": "Mathias"}], "http://schema.org/identifier": [{"@value": "orcid.org/0000-0002-4858-8056"}]}, {"@id": "https://v25.proteinatlas.org/humanproteome/subcellular", "@type": ["http://schema.org/DataSet"], "http://schema.org/creator": [{"@id": "_:N5c81381371a448c48b55832c91e1a8ac"}, {"@id": "_:N4b123d75559d42a8bd8cdd7c499ea6d5"}], "http://schema.org/description": [{"@value": "\t\n\t\tSubcellular methods\n\t\t\n\t\t\t\n\t\t\n\t\n\tThe subcellular resource of the Human Protein Atlas provides high-resolution insights into the expression and spatiotemporal distribution of proteins encoded by 13603 genes (67% of the human protein-coding genes), as well as predictions for an additional 3459 secreted- or membrane proteins, covering a total of 17062 genes (85% of the human protein-coding genes). For each gene, the subcellular distribution of the protein has been investigated by immunofluorescence (ICC-IF) and confocal microscopy in up to three different standard cell lines, selected from a panel of 42 cell lines used in the subcellular resource. For some genes, the protein has also been stained in up to three ciliated cell lines, induced pluripotent stem cells (iPSCs) and/or in human sperm cells. Upon image analysis, the subcellular localization of the protein has been classified into one or more of 49 different organelles and subcellular structures. In addition, the resource includes an annotation of genes that display single-cell variation in protein expression levels and/or subcellular distribution, as well as an extended analysis of cell cycle dependency of such variations. \nThe subcellular resource offers a database for detailed exploration of individual genes and proteins of interest, as well as for systematic analysis of proteomes in a broader context. More information about the content of the resouce, as well as the generation and analysis of the data, can be found in the Methods summary.\nLearn about:\n\nThe subcellular distribution of proteins in standard human cell lines, including ciliated cells and iPSCs.\nThe subcellular distribution of proteins in human sperm.\nThe proteomes of different organelles and subcellular structures.\nSingle-cell variability in the expression levels and/or localizations of proteins.\n"}], "http://schema.org/license": [{"@id": "https://www.proteinatlas.org/about/licence"}], "http://schema.org/name": [{"@value": "Human Protein Atlas - Subcellular"}]}, {"@id": "_:N5c81381371a448c48b55832c91e1a8ac", "@type": ["http://schema.org/Organization"], "http://schema.org/email": [{"@value": "contact@proteinatlas.org"}], "http://schema.org/founder": [{"@id": "_:Nefa12a912f9e48b892e072928f6d1f89"}], "http://schema.org/logo": [{"@id": "https://www.proteinatlas.org/images_static/logo.gif"}], "http://schema.org/name": [{"@value": "Human Protein Atlas"}]}, {"@id": "_:Nefa12a912f9e48b892e072928f6d1f89", "@type": ["http://schema.org/Person"], "http://schema.org/familyName": [{"@value": "Uhlen"}], "http://schema.org/givenName": [{"@value": "Mathias"}], "http://schema.org/identifier": [{"@value": "orcid.org/0000-0002-4858-8056"}]}, {"@id": "_:N4b123d75559d42a8bd8cdd7c499ea6d5", "@type": ["http://schema.org/Organization"], "http://schema.org/email": [{"@value": "contact@proteinatlas.org"}], "http://schema.org/founder": [{"@id": "_:N99d9bc97543542b593db8950c758b266"}], "http://schema.org/logo": [{"@id": "https://www.proteinatlas.org/images_static/logo.gif"}], "http://schema.org/name": [{"@value": "Human Protein Atlas"}]}, {"@id": "_:N99d9bc97543542b593db8950c758b266", "@type": ["http://schema.org/Person"], "http://schema.org/familyName": [{"@value": "Uhlen"}], "http://schema.org/givenName": [{"@value": "Mathias"}], "http://schema.org/identifier": [{"@value": "orcid.org/0000-0002-4858-8056"}]}, {"@id": "https://v25.proteinatlas.org/humanproteome/blood", "@type": ["http://schema.org/DataSet"], "http://schema.org/creator": [{"@id": "_:Na08232b069a34bffab3f15ffcbb6d12e"}, {"@id": "_:N8ca5e015c1274682b9b8fa6af4b5e403"}], "http://schema.org/description": [{"@value": "\t\n\t\tBlood methods\n\t\t\n\t\t\t\n\t\t\n\t\n\tIn the new open access blood resource, we focus on the individual protein levels in blood of both healthy individuals and patients diagnosed with various diseases. \nHere you can explore:\u00a0\n\nthe individual protein levels in blood from healthy individuals and patients diagnosed with diseases\nthe longitudinal blood protein levels in healthy individuals during two years\nthe longitudinal blood protein levels in children through puberty\nthe effect of age, BMI and sex on the individual protein levels in blood\nthe levels of plasma proteins using immune assays and mass spectrometry\n\nTo explore the results for a particular protein, find the relevant gene using the HPA search function and click on the tab \u201cblood\u201d."}], "http://schema.org/license": [{"@id": "https://www.proteinatlas.org/about/licence"}], "http://schema.org/name": [{"@value": "Human Protein Atlas - Blood"}]}, {"@id": "_:Na08232b069a34bffab3f15ffcbb6d12e", "@type": ["http://schema.org/Organization"], "http://schema.org/email": [{"@value": "contact@proteinatlas.org"}], "http://schema.org/founder": [{"@id": "_:Nfbf103a2339e4f9db607ff516dfb76d0"}], "http://schema.org/logo": [{"@id": "https://www.proteinatlas.org/images_static/logo.gif"}], "http://schema.org/name": [{"@value": "Human Protein Atlas"}]}, {"@id": "_:Nfbf103a2339e4f9db607ff516dfb76d0", "@type": ["http://schema.org/Person"], "http://schema.org/familyName": [{"@value": "Uhlen"}], "http://schema.org/givenName": [{"@value": "Mathias"}], "http://schema.org/identifier": [{"@value": "orcid.org/0000-0002-4858-8056"}]}, {"@id": "_:N8ca5e015c1274682b9b8fa6af4b5e403", "@type": ["http://schema.org/Organization"], "http://schema.org/email": [{"@value": "contact@proteinatlas.org"}], "http://schema.org/founder": [{"@id": "_:N8c249eaa127a400d90c3c8a7a7476339"}], "http://schema.org/logo": [{"@id": "https://www.proteinatlas.org/images_static/logo.gif"}], "http://schema.org/name": [{"@value": "Human Protein Atlas"}]}, {"@id": "_:N8c249eaa127a400d90c3c8a7a7476339", "@type": ["http://schema.org/Person"], "http://schema.org/familyName": [{"@value": "Uhlen"}], "http://schema.org/givenName": [{"@value": "Mathias"}], "http://schema.org/identifier": [{"@value": "orcid.org/0000-0002-4858-8056"}]}, {"@id": "https://v25.proteinatlas.org/humanproteome/interaction", "@type": ["http://schema.org/DataSet"], "http://schema.org/creator": [{"@id": "_:N442ae252d58f406cb9c84871cbbb6548"}, {"@id": "_:N1b584c3dea7840ac8b5caf1b313a2115"}], "http://schema.org/description": [{"@value": "The Interaction resource in the Human Protein Atlas focuses on various aspects of human protein interactions, including reported experimental protein-protein interactions and their prediced three-dimensional structures as well as metabolic interactions and pathways. The data is based on external sources complemented with \\\"in-house\\\" analysis. Here you  can explore:\n\npredicted 3D structures for consensus protein-protein interactions\nprotein-protein interaction networks for most genes\nfeatures such as subcellular location and expression specificity displayed on the interaction networks  \npathways/subsystems of metabolic genes \n"}], "http://schema.org/license": [{"@id": "https://www.proteinatlas.org/about/licence"}], "http://schema.org/name": [{"@value": "Human Protein Atlas - Interaction"}]}, {"@id": "_:N442ae252d58f406cb9c84871cbbb6548", "@type": ["http://schema.org/Organization"], "http://schema.org/email": [{"@value": "contact@proteinatlas.org"}], "http://schema.org/founder": [{"@id": "_:N61ce770c7d2b4772ba41abccd3e2b86c"}], "http://schema.org/logo": [{"@id": "https://www.proteinatlas.org/images_static/logo.gif"}], "http://schema.org/name": [{"@value": "Human Protein Atlas"}]}, {"@id": "_:N61ce770c7d2b4772ba41abccd3e2b86c", "@type": ["http://schema.org/Person"], "http://schema.org/familyName": [{"@value": "Uhlen"}], "http://schema.org/givenName": [{"@value": "Mathias"}], "http://schema.org/identifier": [{"@value": "orcid.org/0000-0002-4858-8056"}]}, {"@id": "_:N1b584c3dea7840ac8b5caf1b313a2115", "@type": ["http://schema.org/Organization"], "http://schema.org/email": [{"@value": "contact@proteinatlas.org"}], "http://schema.org/founder": [{"@id": "_:Ne8da7be8352347dabb71a9677b1b1fc0"}], "http://schema.org/logo": [{"@id": "https://www.proteinatlas.org/images_static/logo.gif"}], "http://schema.org/name": [{"@value": "Human Protein Atlas"}]}, {"@id": "_:Ne8da7be8352347dabb71a9677b1b1fc0", "@type": ["http://schema.org/Person"], "http://schema.org/familyName": [{"@value": "Uhlen"}], "http://schema.org/givenName": [{"@value": "Mathias"}], "http://schema.org/identifier": [{"@value": "orcid.org/0000-0002-4858-8056"}]}, {"@id": "https://v25.proteinatlas.org/humanproteome/cancer", "@type": ["http://schema.org/DataSet"], "http://schema.org/creator": [{"@id": "_:Nf57ed01954a34b77a00402b160e65713"}, {"@id": "_:N2877cd0c49cd4f6e922d3897ad8fa7c6"}], "http://schema.org/description": [{"@value": "\t\n\t\tCancer methods\n\t\t\n\t\t\t\n\t\t\n\t\n\tThis resource contains Cancer information based on mRNA expression data from 21 cancer types as well as protein data from 20 cancers analysed by IHC and  11 cancer types analysed using MS. This data is displayed together with millions of in-house generated immunohistochemically stained tissue sections images and Kaplan-Meier plots showing the correlation between mRNA expression of each human protein gene and cancer patient survival. More information about the specific content and the generation and analysis of the data in the resource can be found in the  Methods Summary.\nLearn about:\n\nif the mRNA expression of a gene is prognostic for patient survival in each of the cancer types\nif a gene is enriched in a particular cancer type (specificity)\nthe catalogue of genes elevated in each of the cancer types\n"}], "http://schema.org/license": [{"@id": "https://www.proteinatlas.org/about/licence"}], "http://schema.org/name": [{"@value": "Human Protein Atlas - Cancer"}]}, {"@id": "_:Nf57ed01954a34b77a00402b160e65713", "@type": ["http://schema.org/Organization"], "http://schema.org/email": [{"@value": "contact@proteinatlas.org"}], "http://schema.org/founder": [{"@id": "_:Nedc92392d1614574a06d0d39a7e2944f"}], "http://schema.org/logo": [{"@id": "https://www.proteinatlas.org/images_static/logo.gif"}], "http://schema.org/name": [{"@value": "Human Protein Atlas"}]}, {"@id": "_:Nedc92392d1614574a06d0d39a7e2944f", "@type": ["http://schema.org/Person"], "http://schema.org/familyName": [{"@value": "Uhlen"}], "http://schema.org/givenName": [{"@value": "Mathias"}], "http://schema.org/identifier": [{"@value": "orcid.org/0000-0002-4858-8056"}]}, {"@id": "_:N2877cd0c49cd4f6e922d3897ad8fa7c6", "@type": ["http://schema.org/Organization"], "http://schema.org/email": [{"@value": "contact@proteinatlas.org"}], "http://schema.org/founder": [{"@id": "_:N8d5e9dc8726c410fb7930271d61c7e00"}], "http://schema.org/logo": [{"@id": "https://www.proteinatlas.org/images_static/logo.gif"}], "http://schema.org/name": [{"@value": "Human Protein Atlas"}]}, {"@id": "_:N8d5e9dc8726c410fb7930271d61c7e00", "@type": ["http://schema.org/Person"], "http://schema.org/familyName": [{"@value": "Uhlen"}], "http://schema.org/givenName": [{"@value": "Mathias"}], "http://schema.org/identifier": [{"@value": "orcid.org/0000-0002-4858-8056"}]}, {"@id": "https://v25.proteinatlas.org/humanproteome/structure", "@type": ["http://schema.org/DataSet"], "http://schema.org/creator": [{"@id": "_:N3f4b315d3f0a452c99dc6d617a205c70"}, {"@id": "_:Nfb9f8eba69f04ef3b66fad5edb669c21"}], "http://schema.org/description": [{"@value": "\t\n\t\tStructure methods\n\t\t\n\t\t\t\n\t\t\n\t\n\tThe Structure resource\nThe three-dimensional structure of a protein is directly correlated with its function and of major importance for understanding biological processes and the possibilities for interaction with other proteins. Knowing the structure is also important for understanding how the function could be modulated e.g. for therapeutic purposes.  \nThe Structure resource contains information about the predicted three-dimensional structure of  19904 human proteins and their related isoforms. Interactive 3D protein structures based on predictions generated using the AlphaFold source code are shown with the possibility to highlight selected regions and positions in the structure.  The Protein Browser tool displays a variety of features for the different isoforms and can be used to select splice variants and highlight protein related features such as known antigen sequences, transmembrane regions and InterPro domains directly on the structures. The amino acid positions of population variants and variants with known clinical relevance in the Ensembl Variation database as well as predicted benign and pathological variants from  AlphaMissense can also be displayed. More information about the specific content and the generation and analysis of the data in the section can be found in the Methods Summary. \nLearn about:\n\nthe predicted 3D structure of proteins and their related isoforms\nthe antigen structure for the majority of the antibodies\nthe predicted structure of selected protein features\nthe known and predicted missense variants with clinical significance\nthe known population variants and predicted benign missense variants\n\n\nPREDICTED STRUCTURE\n\t\n\t\t\t\t\n\t\t\n\t\t\t$(function() {\n\t\t\t\tlet viewElement = document.getElementById(\\'structure1001\\');\n\t\t\t\tif (viewElement) {\n\t\t\t\t\tlet proteinViewer = createNGLViewer(viewElement, {skipEvents: true, structureData: {\\\"ENSP00000275493_2-v1\\\":{\\\"chains\\\":{\\\"A\\\":{\\\"antigens\\\":[]}}}}});\n\t\t\t\t\tviewElement.nglobject = proteinViewer;\n\t\t\t\t\tproteinViewer.loadStructure(\\'ENSP00000275493_2-v1\\', 0, \\'\\', false, false, false, false, \\'bfactor\\');\n\t\t\t\t}\n\t\t\t});\n\t\t\n\t\t\t\n\t\nView the structures of EGFR in the Human Protein Atlas\nThe predicted structure of the epidermal growth factor receptor EGFR colored according to a per-residue confidence score (pLDDT) with dark blue representing the highest confidence and orange the lowest confidence.\n\n\nANTIGEN STRUCTURE\n\t\n\t\t\t\t\n\t\t\n\t\t\t$(function() {\n\t\t\t\tlet viewElement = document.getElementById(\\'structure1002\\');\n\t\t\t\tif (viewElement) {\n\t\t\t\t\tlet proteinViewer = createNGLViewer(viewElement, {skipEvents: true, structureData: {\\\"ENSP00000275493_2-v1\\\":{\\\"chains\\\":{\\\"A\\\":{\\\"antigens\\\":[{\\\"start_pos\\\":344,\\\"end_pos\\\":492,\\\"ab\\\":\\\"HPA001200\\\",\\\"chain_name\\\":\\\"A\\\",\\\"identity_percent\\\":-1},{\\\"start_pos\\\":1020,\\\"end_pos\\\":1168,\\\"ab\\\":\\\"HPA018530\\\",\\\"chain_name\\\":\\\"A\\\",\\\"identity_percent\\\":-1}]}}}}});\n\t\t\t\t\tviewElement.nglobject = proteinViewer;\n\t\t\t\t\tproteinViewer.loadStructure(\\'ENSP00000275493_2-v1\\', 1, \\'\\', false, false, false, false, \\'bfactor\\');\n\t\t\t\t}\n\t\t\t});\n\t\t\n\t\t\t\n\t\nView the structures of EGFR in the Human Protein Atlas\nThe predicted structure of the epidermal growth factor receptor EGFR with the sequences of the antigens used to generate the antibodies displayed in red and green. \n\n\n\nKNOWN POPULATION VARIANTS\n\t\n\t\t\t\t\n\t\t\n\t\t\t$(function() {\n\t\t\t\tlet viewElement = document.getElementById(\\'structure1003\\');\n\t\t\t\tif (viewElement) {\n\t\t\t\t\tlet proteinViewer = createNGLViewer(viewElement, {skipEvents: true, structureData: {\\\"ENSP00000275493_2-v1\\\":{\\\"chains\\\":{\\\"A\\\":{\\\"antigens\\\":[]}}}}});\n\t\t\t\t\tviewElement.nglobject = proteinViewer;\n\t\t\t\t\tproteinViewer.loadStructure(\\'ENSP00000275493_2-v1\\', 0, \\'\\', false, true, false, false, \\'bfactor\\');\n\t\t\t\t}\n\t\t\t});\n\t\t\n\t\t\t\n\t\nView the structures of EGFR in the Human Protein Atlas\nThe predicted structure of the epidermal growth factor receptor EGFR with population variants from Ensembl Variation marked in blue.\n\n\nKNOWN CLINICAL VARIANTS\n\t\n\t\t\t\t\n\t\t\n\t\t\t$(function() {\n\t\t\t\tlet viewElement = document.getElementById(\\'structure1004\\');\n\t\t\t\tif (viewElement) {\n\t\t\t\t\tlet proteinViewer = createNGLViewer(viewElement, {skipEvents: true, structureData: {\\\"ENSP00000275493_2-v1\\\":{\\\"chains\\\":{\\\"A\\\":{\\\"antigens\\\":[]}}}}});\n\t\t\t\t\tviewElement.nglobject = proteinViewer;\n\t\t\t\t\tproteinViewer.loadStructure(\\'ENSP00000275493_2-v1\\', 0, \\'\\', true, false, false, false, \\'bfactor\\');\n\t\t\t\t}\n\t\t\t});\n\t\t\n\t\t\t\n\t\nView the structures of EGFR in the Human Protein Atlas\nThe predicted structure of the epidermal growth factor receptor EGFR with variants classified as pathogenic or likely pathogenic in the Ensembl Variation clinical data set marked in blue.\n\n\n\nPREDICTED  BENIGN VARIANTS\n\t\n\t\t\t\t\n\t\t\n\t\t\t$(function() {\n\t\t\t\tlet viewElement = document.getElementById(\\'structure1005\\');\n\t\t\t\tif (viewElement) {\n\t\t\t\t\tlet proteinViewer = createNGLViewer(viewElement, {skipEvents: true, structureData: {\\\"ENSP00000275493_2-v1\\\":{\\\"chains\\\":{\\\"A\\\":{\\\"antigens\\\":[]}}}}});\n\t\t\t\t\tviewElement.nglobject = proteinViewer;\n\t\t\t\t\tproteinViewer.loadStructure(\\'ENSP00000275493_2-v1\\', 0, \\'\\', false, false, false, true, \\'bfactor\\');\n\t\t\t\t}\n\t\t\t});\n\t\t\n\t\t\t\n\t\nView the structures of EGFR in the Human Protein Atlas\nThe predicted structure of the epidermal growth factor receptor EGFR with \\\"likely benign\\\" missense variants according to AlphaMissense predictions marked in blue.\n\n\nPREDICTED PATHOGENIC VARIANTS\n\t\n\t\t\t\t\n\t\t\n\t\t\t$(function() {\n\t\t\t\tlet viewElement = document.getElementById(\\'structure1006\\');\n\t\t\t\tif (viewElement) {\n\t\t\t\t\tlet proteinViewer = createNGLViewer(viewElement, {skipEvents: true, structureData: {\\\"ENSP00000275493_2-v1\\\":{\\\"chains\\\":{\\\"A\\\":{\\\"antigens\\\":[]}}}}});\n\t\t\t\t\tviewElement.nglobject = proteinViewer;\n\t\t\t\t\tproteinViewer.loadStructure(\\'ENSP00000275493_2-v1\\', 0, \\'\\', false, false, true, false, \\'bfactor\\');\n\t\t\t\t}\n\t\t\t});\n\t\t\n\t\t\t\n\t\nView the structures of EGFR in the Human Protein Atlas\nThe predicted structure of the epidermal growth factor receptor EGFR with \\\"likely pathogenic\\\" missense variants according to AlphaMissense predictions marked in blue.\n\n"}], "http://schema.org/license": [{"@id": "https://www.proteinatlas.org/about/licence"}], "http://schema.org/name": [{"@value": "Human Protein Atlas - Structure"}]}, {"@id": "_:N3f4b315d3f0a452c99dc6d617a205c70", "@type": ["http://schema.org/Organization"], "http://schema.org/email": [{"@value": "contact@proteinatlas.org"}], "http://schema.org/founder": [{"@id": "_:N1cf62cd650954fd89c73f9a1a3492af9"}], "http://schema.org/logo": [{"@id": "https://www.proteinatlas.org/images_static/logo.gif"}], "http://schema.org/name": [{"@value": "Human Protein Atlas"}]}, {"@id": "_:N1cf62cd650954fd89c73f9a1a3492af9", "@type": ["http://schema.org/Person"], "http://schema.org/familyName": [{"@value": "Uhlen"}], "http://schema.org/givenName": [{"@value": "Mathias"}], "http://schema.org/identifier": [{"@value": "orcid.org/0000-0002-4858-8056"}]}, {"@id": "_:Nfb9f8eba69f04ef3b66fad5edb669c21", "@type": ["http://schema.org/Organization"], "http://schema.org/email": [{"@value": "contact@proteinatlas.org"}], "http://schema.org/founder": [{"@id": "_:N994829d67e6942dabd6b313d9db946e3"}], "http://schema.org/logo": [{"@id": "https://www.proteinatlas.org/images_static/logo.gif"}], "http://schema.org/name": [{"@value": "Human Protein Atlas"}]}, {"@id": "_:N994829d67e6942dabd6b313d9db946e3", "@type": ["http://schema.org/Person"], "http://schema.org/familyName": [{"@value": "Uhlen"}], "http://schema.org/givenName": [{"@value": "Mathias"}], "http://schema.org/identifier": [{"@value": "orcid.org/0000-0002-4858-8056"}]}, {"@id": "https://v25.proteinatlas.org/humanproteome/single+cell", "@type": ["http://schema.org/DataSet"], "http://schema.org/creator": [{"@id": "_:Ne9355a58e44c41c1be88c75d6ff9a821"}, {"@id": "_:N4857010af3014145a49b60e0922cabe2"}], "http://schema.org/description": [{"@value": "The Single Cell resource of the Human Protein Atlas presents comprehensive data on gene expression across various human tissues and cell types, utilizing single cell RNA sequencing (scRNAseq), cell sorting, single nuclei RNA sequencing (snRNAseq), and bulk RNAseq correlation analyses. The resource provides insights into mRNA and protein expression patterns, gene specificity, and expression clustering with single cell types, immune cells and brain single nuclei. The Single Cell Resource includes four main datasets:\n\nThe Single cell type section, providing the expression profiles across 154 cell types from 34 human tissues, and cell type specificity based on gene expression. \nThe Tissue cell type section, providing the predicted cell-type expression specificity based on bulk RNAseq\nThe Single nuclei brain section, providing more details regarding cell type specificity within the brain, based on single nuclei RNAseq\nThe Immune cell section, providing expression comparison between sorted immune cells\n\nLearn more about each of these four parts down below, and explore the details of each dataset, or serach for a gene and browse the expression details side by side across the different datasets on the gene summary pages. More information about the content, the generation and analysis of the data in this resource can be found under respective link or here for single cell type, tissue cell type, single nuclei brain and immune cell. Additionally, each focused section is based on different datasets, see more details here for single cell type, tissue cell type (using GTEx RNAseq, single nuclei brain and immune cell. "}], "http://schema.org/license": [{"@id": "https://www.proteinatlas.org/about/licence"}], "http://schema.org/name": [{"@value": "Human Protein Atlas - Single cell"}]}, {"@id": "_:Ne9355a58e44c41c1be88c75d6ff9a821", "@type": ["http://schema.org/Organization"], "http://schema.org/email": [{"@value": "contact@proteinatlas.org"}], "http://schema.org/founder": [{"@id": "_:N1e5cf8f010b94858abc713745f4897af"}], "http://schema.org/logo": [{"@id": "https://www.proteinatlas.org/images_static/logo.gif"}], "http://schema.org/name": [{"@value": "Human Protein Atlas"}]}, {"@id": "_:N1e5cf8f010b94858abc713745f4897af", "@type": ["http://schema.org/Person"], "http://schema.org/familyName": [{"@value": "Uhlen"}], "http://schema.org/givenName": [{"@value": "Mathias"}], "http://schema.org/identifier": [{"@value": "orcid.org/0000-0002-4858-8056"}]}, {"@id": "_:N4857010af3014145a49b60e0922cabe2", "@type": ["http://schema.org/Organization"], "http://schema.org/email": [{"@value": "contact@proteinatlas.org"}], "http://schema.org/founder": [{"@id": "_:N5dc45b671c1c4cc780f0f1c52b056ead"}], "http://schema.org/logo": [{"@id": "https://www.proteinatlas.org/images_static/logo.gif"}], "http://schema.org/name": [{"@value": "Human Protein Atlas"}]}, {"@id": "_:N5dc45b671c1c4cc780f0f1c52b056ead", "@type": ["http://schema.org/Person"], "http://schema.org/familyName": [{"@value": "Uhlen"}], "http://schema.org/givenName": [{"@value": "Mathias"}], "http://schema.org/identifier": [{"@value": "orcid.org/0000-0002-4858-8056"}]}, {"@id": "https://v25.proteinatlas.org", "@type": ["http://schema.org/DataCatalog"], "http://schema.org/citation": [{"@id": "_:Nedf4a412076d4017afd8a93355a371d5"}, {"@id": "_:Na1a0badc1c5c4cdd8587870870cd625f"}], "http://schema.org/dataset": [{"@id": "https://v25.proteinatlas.org/humanproteome/structure"}, {"@id": "https://v25.proteinatlas.org/humanproteome/interaction"}, {"@id": "https://v25.proteinatlas.org/humanproteome/brain"}, {"@id": "https://v25.proteinatlas.org/humanproteome/blood"}, {"@id": "https://v25.proteinatlas.org/humanproteome/cell+line"}, {"@id": "https://v25.proteinatlas.org/humanproteome/single+cell"}, {"@id": "https://v25.proteinatlas.org/humanproteome/subcellular"}, {"@id": "https://v25.proteinatlas.org/humanproteome/cancer"}, {"@id": "https://v25.proteinatlas.org/humanproteome/tissue"}], "http://schema.org/dateModified": [{"@type": "http://schema.org/Date", "@value": "2025-11-11"}], "http://schema.org/description": [{"@value": "The Human Protein Atlas is a Sweden-based program initiated in 2003 with the aim to map all the human proteins in cells, tissues, and organs using an integration of various omics technologies, including antibody-based imaging, mass spectrometry-based proteomics, transcriptomics, and systems biology. All the data in the knowledge resource is open access to allow scientists both in academia and industry to freely access the data for exploration of the human proteome.\n\nThe Human Protein Atlas consists of nine separate resources, each focusing on a particular aspect of the genome-wide analysis of the human proteins:\n\n\nThe Tissue resource, showing the distribution of the proteins across all major tissues and organs in the human body\nThe Brain resource, exploring the distribution of proteins in various regions of the mammalian brain\nThe Single Cell resource, showing gene expression in immune cells and human single cell types from bulk,single cell and single nuclei RNA-seq\nThe Subcellular resource, showing the subcellular localization of proteins in single cells\nThe Cancer resource, showing the impact of protein levels for the survival of patients with cancer\nThe Blood resource, describing proteins detected in blood and showing protein levels in blood in patients with different diseases\nThe Cell line resource, showing gene expression in human cancer cell lines and the best models for common cancers\nThe Structure resource, showing predicted 3D structures for most protein isoforms highlighting antigen sites and variants\nThe Interaction resource, showing protein-protein and metabolic interaction networks including AF3 predicted 3D structures \n\nThe Human Protein Atlas is a Global Core Biodata Resource in life sciences, based at SciLifeLab. As an open-access initiative, Human Protein Atlas has further been selected by  the organization ELIXIR as a European core resource due to its fundamental importance for a wider life science community. The Human Protein Atlas consortium is mainly funded by the Knut and Alice Wallenberg Foundation. 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