[{"@graph": [{"@id": "https://bioschemas.org/profiles/ChemicalSubstance/0.4-RELEASE", "@type": ["http://schema.org/CreativeWork"]}, {"@id": "https://pharos.nih.gov/targets/RRP7A", "@type": ["http://schema.org/Protein"], "http://purl.org/dc/terms/conformsTo": [{"@id": "https://bioschemas.org/profiles/Protein/0.11-RELEASE"}], "http://schema.org/identifier": [{"@id": "_:N0f0562d90bd240d89a7be2f6a4f3fc98"}, {"@id": "_:N4e040cbeacd148a99d0ed597358b6fb8"}], "http://schema.org/mainEntityOfPage": [{"@id": "https://pharos.nih.gov/targets/RRP7A"}], "http://schema.org/name": [{"@value": "Ribosomal RNA-processing protein 7 homolog A"}], "http://schema.org/url": [{"@id": "https://pharos.nih.gov/targets/RRP7A"}]}, {"@id": "_:N0f0562d90bd240d89a7be2f6a4f3fc98", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "UniProt ID"}], "http://schema.org/value": [{"@value": "Q9Y3A4"}]}, {"@id": "_:N4e040cbeacd148a99d0ed597358b6fb8", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Gene Symbol"}], "http://schema.org/value": [{"@value": "RRP7A"}]}, {"@id": "https://bioschemas.org/profiles/Protein/0.11-RELEASE", "@type": ["http://schema.org/CreativeWork"]}, {"@id": "https://pharos.nih.gov/targets/CDCA8", "@type": ["http://schema.org/Protein"], "http://purl.org/dc/terms/conformsTo": [{"@id": "https://bioschemas.org/profiles/Protein/0.11-RELEASE"}], "http://schema.org/identifier": [{"@id": "_:N39d862b3172b42ba9c34d200d248c2bd"}, {"@id": "_:Na64b5fd145be45f5a34f17f163107378"}], "http://schema.org/mainEntityOfPage": [{"@id": "https://pharos.nih.gov/targets/CDCA8"}], "http://schema.org/name": [{"@value": "Borealin"}], "http://schema.org/url": [{"@id": "https://pharos.nih.gov/targets/CDCA8"}]}, {"@id": "_:N39d862b3172b42ba9c34d200d248c2bd", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Gene Symbol"}], "http://schema.org/value": [{"@value": "CDCA8"}]}, {"@id": "_:Na64b5fd145be45f5a34f17f163107378", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "UniProt ID"}], "http://schema.org/value": [{"@value": "Q53HL2"}]}, {"@id": "https://pharos.nih.gov/diseases/Hyperalgesia", "@type": ["http://schema.org/MedicalCondition"], "http://schema.org/identifier": [{"@id": "_:Nfcbcfe682916401eb9b8b1e9905e0d19"}], "http://schema.org/mainEntityOfPage": [{"@id": "https://pharos.nih.gov/diseases/Hyperalgesia"}], "http://schema.org/name": [{"@value": "Hyperalgesia"}], "http://schema.org/url": [{"@id": "https://pharos.nih.gov/diseases/Hyperalgesia"}]}, {"@id": "_:Nfcbcfe682916401eb9b8b1e9905e0d19", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "MONDO ID"}]}, {"@id": "https://pharos.nih.gov/diseases/Wilson%20disease", "@type": ["http://schema.org/MedicalCondition"], "http://schema.org/identifier": [{"@id": "_:N57f0818e52a04f1f9345f2e8212ed260"}], "http://schema.org/mainEntityOfPage": [{"@id": "https://pharos.nih.gov/diseases/Wilson%20disease"}], "http://schema.org/name": [{"@value": "Wilson disease"}], "http://schema.org/url": [{"@id": "https://pharos.nih.gov/diseases/Wilson%20disease"}]}, {"@id": "_:N57f0818e52a04f1f9345f2e8212ed260", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "MONDO ID"}], "http://schema.org/value": [{"@value": "MONDO:0010200"}]}, {"@id": "https://pharos.nih.gov/ligands/4UXPNBHU6CAL", "@type": ["http://schema.org/ChemicalSubstance"], "http://purl.org/dc/terms/conformsTo": [{"@id": "https://bioschemas.org/profiles/ChemicalSubstance/0.4-RELEASE"}], "http://schema.org/chemicalComposition": [{"@value": "CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4"}], "http://schema.org/identifier": [{"@id": "_:N95efefe76d3f4fd295a53cc817575fab"}, {"@id": "_:Nee4b522cb1ee456f9d8ed890fd78b3e6"}, {"@id": "_:N217dc234d07443cd9801740ce2175c48"}], "http://schema.org/mainEntityOfPage": [{"@id": "https://pharos.nih.gov/ligands/4UXPNBHU6CAL"}], "http://schema.org/name": [{"@value": "SID103905531"}], "http://schema.org/url": [{"@id": "https://pharos.nih.gov/ligands/4UXPNBHU6CAL"}]}, {"@id": "_:N95efefe76d3f4fd295a53cc817575fab", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Name"}], "http://schema.org/value": [{"@value": "SID103905531"}]}, {"@id": "_:Nee4b522cb1ee456f9d8ed890fd78b3e6", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "ChEMBL"}], "http://schema.org/url": [{"@id": "https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1980995/"}], "http://schema.org/value": [{"@value": "CHEMBL1980995"}]}, {"@id": "_:N217dc234d07443cd9801740ce2175c48", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "PubChem"}], "http://schema.org/url": [{"@id": "https://pubchem.ncbi.nlm.nih.gov/compound/5279"}], "http://schema.org/value": [{"@value": "5279"}]}, {"@id": "https://pharos.nih.gov/diseases/Mental%20Depression", "@type": ["http://schema.org/MedicalCondition"], "http://schema.org/identifier": [{"@id": "_:N1e75b325f8b24d1fb8e938d7367c5f78"}], "http://schema.org/mainEntityOfPage": [{"@id": "https://pharos.nih.gov/diseases/Mental%20Depression"}], "http://schema.org/name": [{"@value": "Mental Depression"}], "http://schema.org/url": [{"@id": "https://pharos.nih.gov/diseases/Mental%20Depression"}]}, {"@id": "_:N1e75b325f8b24d1fb8e938d7367c5f78", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "MONDO ID"}]}, {"@id": "https://pharos.nih.gov/diseases/cocaine%20dependence", "@type": ["http://schema.org/MedicalCondition"], "http://schema.org/identifier": [{"@id": "_:N569a33a2c9d747dc9ea802c25b71bb39"}], "http://schema.org/mainEntityOfPage": [{"@id": "https://pharos.nih.gov/diseases/cocaine%20dependence"}], "http://schema.org/name": [{"@value": "cocaine dependence"}], "http://schema.org/url": [{"@id": "https://pharos.nih.gov/diseases/cocaine%20dependence"}]}, {"@id": "_:N569a33a2c9d747dc9ea802c25b71bb39", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "MONDO ID"}], "http://schema.org/value": [{"@value": "MONDO:0005186"}]}, {"@id": "https://pharos.nih.gov/targets/CAMK2D", "@type": ["http://schema.org/Protein"], "http://purl.org/dc/terms/conformsTo": [{"@id": "https://bioschemas.org/profiles/Protein/0.11-RELEASE"}], "http://schema.org/identifier": [{"@id": "_:N26b802396b994447ae57ee68174f2b83"}, {"@id": "_:N96e282b211b541c8a176267c7a35c021"}], "http://schema.org/mainEntityOfPage": [{"@id": "https://pharos.nih.gov/targets/CAMK2D"}], "http://schema.org/name": [{"@value": "Calcium/calmodulin-dependent protein kinase type II subunit delta"}], "http://schema.org/url": [{"@id": "https://pharos.nih.gov/targets/CAMK2D"}]}, {"@id": "_:N26b802396b994447ae57ee68174f2b83", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "UniProt ID"}], "http://schema.org/value": [{"@value": "Q13557"}]}, {"@id": "_:N96e282b211b541c8a176267c7a35c021", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Gene Symbol"}], "http://schema.org/value": [{"@value": "CAMK2D"}]}, {"@id": "https://pharos.nih.gov/ligands/AFCJ95Q3AR7F", "@type": ["http://schema.org/ChemicalSubstance"], "http://purl.org/dc/terms/conformsTo": [{"@id": "https://bioschemas.org/profiles/ChemicalSubstance/0.4-RELEASE"}], "http://schema.org/chemicalComposition": [{"@value": "CC(C)(C)n1nc(Cc2cccc3ccccc23)c2c(N)ncnc21"}], "http://schema.org/identifier": [{"@id": "_:N58d85d82c8334f069de1993a0a280439"}, {"@id": "_:Nc501a3cd4a784b8e86d3b54fbd57498e"}, {"@id": "_:N764b00cb59f24c439cf11900984acfcf"}], "http://schema.org/mainEntityOfPage": [{"@id": "https://pharos.nih.gov/ligands/AFCJ95Q3AR7F"}], "http://schema.org/name": [{"@value": "1-tert-butyl-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine"}], "http://schema.org/url": [{"@id": "https://pharos.nih.gov/ligands/AFCJ95Q3AR7F"}]}, {"@id": "_:N58d85d82c8334f069de1993a0a280439", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Name"}], "http://schema.org/value": [{"@value": "1-tert-butyl-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine"}]}, {"@id": "_:Nc501a3cd4a784b8e86d3b54fbd57498e", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "PubChem"}], "http://schema.org/url": [{"@id": "https://pubchem.ncbi.nlm.nih.gov/compound/5154691"}], "http://schema.org/value": [{"@value": "5154691"}]}, {"@id": "_:N764b00cb59f24c439cf11900984acfcf", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "ChEMBL"}], "http://schema.org/url": [{"@id": "https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL573578/"}], "http://schema.org/value": [{"@value": "CHEMBL573578"}]}, {"@id": "https://pharos.nih.gov/targets/CAMK2B", "@type": ["http://schema.org/Protein"], "http://purl.org/dc/terms/conformsTo": [{"@id": "https://bioschemas.org/profiles/Protein/0.11-RELEASE"}], "http://schema.org/identifier": [{"@id": "_:N5ca89716cb544349bf1d5780342c37ab"}, {"@id": "_:Nb4c005700793403085d09f53d29c06ed"}], "http://schema.org/mainEntityOfPage": [{"@id": "https://pharos.nih.gov/targets/CAMK2B"}], "http://schema.org/name": [{"@value": "Calcium/calmodulin-dependent protein kinase type II subunit beta"}], "http://schema.org/url": [{"@id": "https://pharos.nih.gov/targets/CAMK2B"}]}, {"@id": "_:N5ca89716cb544349bf1d5780342c37ab", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Gene Symbol"}], "http://schema.org/value": [{"@value": "CAMK2B"}]}, {"@id": "_:Nb4c005700793403085d09f53d29c06ed", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "UniProt ID"}], "http://schema.org/value": [{"@value": "Q13554"}]}, {"@id": "https://pharos.nih.gov/ligands/JRQZXU1XYFJW", "@type": ["http://schema.org/ChemicalSubstance"], "http://purl.org/dc/terms/conformsTo": [{"@id": "https://bioschemas.org/profiles/ChemicalSubstance/0.4-RELEASE"}], "http://schema.org/chemicalComposition": [{"@value": "CO[C@@H]1[C@H](N(C)CCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4"}], "http://schema.org/identifier": [{"@id": "_:N85b32656eaa343ecb8748b709a6c15a7"}, {"@id": "_:N0e0f49c8c5f44901a70bcbac0b0a5c43"}, {"@id": "_:N27e5384063cc44ab8bc7e086ebbb138c"}], "http://schema.org/mainEntityOfPage": [{"@id": "https://pharos.nih.gov/ligands/JRQZXU1XYFJW"}], "http://schema.org/name": [{"@value": "CHEMBL4576489"}], "http://schema.org/url": [{"@id": "https://pharos.nih.gov/ligands/JRQZXU1XYFJW"}]}, {"@id": "_:N85b32656eaa343ecb8748b709a6c15a7", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "PubChem"}], "http://schema.org/url": [{"@id": "https://pubchem.ncbi.nlm.nih.gov/compound/155552127"}], "http://schema.org/value": [{"@value": "155552127"}]}, {"@id": "_:N0e0f49c8c5f44901a70bcbac0b0a5c43", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Name"}], "http://schema.org/value": [{"@value": "CHEMBL4576489"}]}, {"@id": "_:N27e5384063cc44ab8bc7e086ebbb138c", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "ChEMBL"}], "http://schema.org/url": [{"@id": "https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL4576489/"}], "http://schema.org/value": [{"@value": "CHEMBL4576489"}]}, {"@id": "_:N609ecb075c1c40519f95adf08ce0dfd6", "@type": ["http://schema.org/Rating"], "http://schema.org/author": [{"@id": "_:Ndaefa634a70e4a2baac7b0d6faa226fa"}], "http://schema.org/image": [{"@id": "https://pharos.nih.gov/assets/images/Tchem.png"}], "http://schema.org/name": [{"@value": "Target Development Level"}], "http://schema.org/ratingExplanation": [{"@value": "These are targets that have at least one ChEMBL compound with an activity cutoff of < 30 nM, and satisfy the criteria for lower categories."}], "http://schema.org/ratingValue": [{"@value": "Tchem"}], "http://schema.org/reviewAspect": [{"@value": "The degree to which proteins are studied or not studied, as evidenced by publications, tool compounds and other features."}]}, {"@id": "_:Ndaefa634a70e4a2baac7b0d6faa226fa", "@type": ["http://schema.org/Organization"], "http://schema.org/logo": [{"@id": "https://commonfund.nih.gov/sites/default/files/IDG_LOGO_UPRIGHT_3.png"}], "http://schema.org/name": [{"@value": "Illuminating the Druggable Genome (IDG)"}], "http://schema.org/url": [{"@id": "https://commonfund.nih.gov/idg"}]}, {"@id": "https://pharos.nih.gov/targets/CAMK2G", "@type": ["http://schema.org/Protein"], "http://purl.org/dc/terms/conformsTo": [{"@id": "https://bioschemas.org/profiles/Protein/0.11-RELEASE"}], "http://schema.org/identifier": [{"@id": "_:N445a89402fc3444399462e9c28440022"}, {"@id": "_:Na4f969bb359747ea863ffc82bb983d0d"}], "http://schema.org/mainEntityOfPage": [{"@id": "https://pharos.nih.gov/targets/CAMK2G"}], "http://schema.org/name": [{"@value": "Calcium/calmodulin-dependent protein kinase type II subunit gamma"}], "http://schema.org/url": [{"@id": "https://pharos.nih.gov/targets/CAMK2G"}]}, {"@id": "_:N445a89402fc3444399462e9c28440022", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Gene Symbol"}], "http://schema.org/value": [{"@value": "CAMK2G"}]}, {"@id": "_:Na4f969bb359747ea863ffc82bb983d0d", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "UniProt ID"}], "http://schema.org/value": [{"@value": "Q13555"}]}, {"@id": "https://pharos.nih.gov/ligands/JJKPSGPHHFRR", "@type": ["http://schema.org/ChemicalSubstance"], "http://purl.org/dc/terms/conformsTo": [{"@id": "https://bioschemas.org/profiles/ChemicalSubstance/0.4-RELEASE"}], "http://schema.org/chemicalComposition": [{"@value": "C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O"}], "http://schema.org/identifier": [{"@id": "_:N0759c244f5aa417f9867db8a90f2cdc1"}, {"@id": "_:N65ba298c0db84800b200ab5d127f3f6d"}, {"@id": "_:Nb367188790334b22b7269a217799a6e5"}, {"@id": "_:N2e31bcde9b9e4fdeb9e5a9e1493434ed"}], "http://schema.org/mainEntityOfPage": [{"@id": "https://pharos.nih.gov/ligands/JJKPSGPHHFRR"}], "http://schema.org/name": [{"@value": "lestaurtinib"}], "http://schema.org/url": [{"@id": "https://pharos.nih.gov/ligands/JJKPSGPHHFRR"}]}, {"@id": "_:N0759c244f5aa417f9867db8a90f2cdc1", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "ChEMBL"}], "http://schema.org/url": [{"@id": "https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL603469/"}], "http://schema.org/value": [{"@value": "CHEMBL603469"}]}, {"@id": "_:N65ba298c0db84800b200ab5d127f3f6d", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "PubChem"}], "http://schema.org/url": [{"@id": "https://pubchem.ncbi.nlm.nih.gov/compound/126565"}], "http://schema.org/value": [{"@value": "126565"}]}, {"@id": "_:Nb367188790334b22b7269a217799a6e5", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Name"}], "http://schema.org/value": [{"@value": "lestaurtinib"}]}, {"@id": "_:N2e31bcde9b9e4fdeb9e5a9e1493434ed", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Guide to Pharmacology"}], "http://schema.org/url": [{"@id": "http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5672"}], "http://schema.org/value": [{"@value": "5672"}]}, {"@id": "https://pharos.nih.gov/ligands/midostaurin", "@type": ["http://schema.org/ChemicalSubstance"], "http://purl.org/dc/terms/conformsTo": [{"@id": "https://bioschemas.org/profiles/ChemicalSubstance/0.4-RELEASE"}], "http://schema.org/chemicalComposition": [{"@value": "CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c1c1n2c2ccccc2c1c1c3CNC1=O)N(C(=O)c1ccccc1)C"}], "http://schema.org/identifier": [{"@id": "_:N1dcb3e5a20fc44938688bf3d56eaedb4"}, {"@id": "_:N04f0160e4b804432a08de4b48542e83c"}, {"@id": "_:N2f3d47638885481b8b1326e1533f755f"}, {"@id": "_:N47c4453b8e6a460c8a3da3dfcddef398"}, {"@id": "_:N97c8f980e34a494387d1f0756e58f890"}], "http://schema.org/mainEntityOfPage": [{"@id": "https://pharos.nih.gov/ligands/midostaurin"}], "http://schema.org/name": [{"@value": "midostaurin"}], "http://schema.org/potentialUse": [{"@value": "FDA Approved Drug"}], "http://schema.org/url": [{"@id": "https://pharos.nih.gov/ligands/midostaurin"}]}, {"@id": "_:N1dcb3e5a20fc44938688bf3d56eaedb4", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "DrugCentral"}], "http://schema.org/url": [{"@id": "http://drugcentral.org/drugcard/5231"}], "http://schema.org/value": [{"@value": "5231"}]}, {"@id": "_:N04f0160e4b804432a08de4b48542e83c", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Guide to Pharmacology"}], "http://schema.org/url": [{"@id": "http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5702"}], "http://schema.org/value": [{"@value": "5702"}]}, {"@id": "_:N2f3d47638885481b8b1326e1533f755f", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "UNII"}], "http://schema.org/url": [{"@id": "https://drugs.ncats.io/drug/ID912S5VON"}], "http://schema.org/value": [{"@value": "ID912S5VON"}]}, {"@id": "_:N47c4453b8e6a460c8a3da3dfcddef398", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "PubChem"}], "http://schema.org/url": [{"@id": "https://pubchem.ncbi.nlm.nih.gov/compound/9829523"}], "http://schema.org/value": [{"@value": "9829523"}]}, {"@id": "_:N97c8f980e34a494387d1f0756e58f890", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "ChEMBL"}], "http://schema.org/url": [{"@id": "https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL608533/"}], "http://schema.org/value": [{"@value": "CHEMBL608533"}]}, {"@id": "https://pharos.nih.gov/ligands/G3KAGHS4CG2M", "@type": ["http://schema.org/ChemicalSubstance"], "http://purl.org/dc/terms/conformsTo": [{"@id": "https://bioschemas.org/profiles/ChemicalSubstance/0.4-RELEASE"}], "http://schema.org/chemicalComposition": [{"@value": "CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4"}], "http://schema.org/identifier": [{"@id": "_:N7e65cd61a1054c54bb90ad1170be5798"}, {"@id": "_:N38d66b8e597a43d9b6cd92213b39aa18"}, {"@id": "_:Ndcfc8231016c4d4696d61fe71011c64e"}], "http://schema.org/mainEntityOfPage": [{"@id": "https://pharos.nih.gov/ligands/G3KAGHS4CG2M"}], "http://schema.org/name": [{"@value": "[3-{2-[(3,5-Dimethyl-1H-pyrrol-2-yl-kappaN)methylidene]-2H-pyrrol-5-yl-kappaN}-N-(2-{2-[2-(2-{[(5S,6R,7R,9R)-6-methoxy-5-methyl-14-oxo-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-7-yl]amino}ethoxy)ethoxy]ethoxy}ethyl)propanamidato](difluoro)borone"}], "http://schema.org/url": [{"@id": "https://pharos.nih.gov/ligands/G3KAGHS4CG2M"}]}, {"@id": "_:N7e65cd61a1054c54bb90ad1170be5798", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Name"}], "http://schema.org/value": [{"@value": "[3-{2-[(3,5-Dimethyl-1H-pyrrol-2-yl-kappaN)methylidene]-2H-pyrrol-5-yl-kappaN}-N-(2-{2-[2-(2-{[(5S,6R,7R,9R)-6-methoxy-5-methyl-14-oxo-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-7-yl]amino}ethoxy)ethoxy]ethoxy}ethyl)propanamidato](difluoro)borone"}]}, {"@id": "_:N38d66b8e597a43d9b6cd92213b39aa18", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "ChEMBL"}], "http://schema.org/url": [{"@id": "https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL4465866/"}], "http://schema.org/value": [{"@value": "CHEMBL4465866"}]}, {"@id": "_:Ndcfc8231016c4d4696d61fe71011c64e", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "PubChem"}], "http://schema.org/url": [{"@id": "https://pubchem.ncbi.nlm.nih.gov/compound/155531579"}], "http://schema.org/value": [{"@value": "155531579"}]}, {"@id": "https://pharos.nih.gov/diseases/ovarian%20cancer", "@type": ["http://schema.org/MedicalCondition"], "http://schema.org/identifier": [{"@id": "_:Nb12d4a2c980a4ff3b1609103efb7250e"}], "http://schema.org/mainEntityOfPage": [{"@id": "https://pharos.nih.gov/diseases/ovarian%20cancer"}], "http://schema.org/name": [{"@value": "ovarian cancer"}], "http://schema.org/url": [{"@id": "https://pharos.nih.gov/diseases/ovarian%20cancer"}]}, {"@id": "_:Nb12d4a2c980a4ff3b1609103efb7250e", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "MONDO ID"}], "http://schema.org/value": [{"@value": "MONDO:0008170"}]}, {"@id": "https://pharos.nih.gov/diseases/intellectual%20disability%2C%20autosomal%20dominant%2053", "@type": ["http://schema.org/MedicalCondition"], "http://schema.org/identifier": [{"@id": "_:N06c4cfffa7ed4fa0863598c6991c14d6"}], "http://schema.org/mainEntityOfPage": [{"@id": "https://pharos.nih.gov/diseases/intellectual%20disability%2C%20autosomal%20dominant%2053"}], "http://schema.org/name": [{"@value": "intellectual disability, autosomal dominant 53"}], "http://schema.org/url": [{"@id": "https://pharos.nih.gov/diseases/intellectual%20disability%2C%20autosomal%20dominant%2053"}]}, {"@id": "_:N06c4cfffa7ed4fa0863598c6991c14d6", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "MONDO ID"}], "http://schema.org/value": [{"@value": "MONDO:0030919"}]}, {"@id": "https://pharos.nih.gov/targets/ARMC1", "@type": ["http://schema.org/Protein"], "http://purl.org/dc/terms/conformsTo": [{"@id": "https://bioschemas.org/profiles/Protein/0.11-RELEASE"}], "http://schema.org/identifier": [{"@id": "_:N496e2becfc914b549280f6eae512b89f"}, {"@id": "_:N3fe666f10e4a4f2982241a92ffa1379c"}], "http://schema.org/mainEntityOfPage": [{"@id": "https://pharos.nih.gov/targets/ARMC1"}], "http://schema.org/name": [{"@value": "Armadillo repeat-containing protein 1"}], "http://schema.org/url": [{"@id": "https://pharos.nih.gov/targets/ARMC1"}]}, {"@id": "_:N496e2becfc914b549280f6eae512b89f", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "UniProt ID"}], "http://schema.org/value": [{"@value": "Q9NVT9"}]}, {"@id": "_:N3fe666f10e4a4f2982241a92ffa1379c", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Gene Symbol"}], "http://schema.org/value": [{"@value": "ARMC1"}]}, {"@id": "https://pharos.nih.gov/diseases/Hepatomegaly", "@type": ["http://schema.org/MedicalCondition"], "http://schema.org/identifier": [{"@id": "_:Nf73c845db1e74317b6f6d69487b78af5"}], "http://schema.org/mainEntityOfPage": [{"@id": "https://pharos.nih.gov/diseases/Hepatomegaly"}], "http://schema.org/name": [{"@value": "Hepatomegaly"}], "http://schema.org/url": [{"@id": "https://pharos.nih.gov/diseases/Hepatomegaly"}]}, {"@id": "_:Nf73c845db1e74317b6f6d69487b78af5", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "MONDO ID"}]}, {"@id": "https://pharos.nih.gov/diseases/malignant%20ependymoma", "@type": ["http://schema.org/MedicalCondition"], "http://schema.org/identifier": [{"@id": "_:Ncf6bec7f188945a69a300aa081773cb5"}], "http://schema.org/mainEntityOfPage": [{"@id": "https://pharos.nih.gov/diseases/malignant%20ependymoma"}], "http://schema.org/name": [{"@value": "malignant ependymoma"}], "http://schema.org/url": [{"@id": "https://pharos.nih.gov/diseases/malignant%20ependymoma"}]}, {"@id": "_:Ncf6bec7f188945a69a300aa081773cb5", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "MONDO ID"}], "http://schema.org/value": [{"@value": "MONDO:0021191"}]}, {"@id": "https://pharos.nih.gov/ligands/Q8TW62QMB593", "@type": ["http://schema.org/ChemicalSubstance"], "http://purl.org/dc/terms/conformsTo": [{"@id": "https://bioschemas.org/profiles/ChemicalSubstance/0.4-RELEASE"}], "http://schema.org/chemicalComposition": [{"@value": "OCCN(S(=O)(=O)c1ccc(cc1)OC)c1ccccc1CN(C/C=C/c1ccc(cc1)Cl)C"}], "http://schema.org/identifier": [{"@id": "_:Ne8eea76a803e438db9a205069861007b"}, {"@id": "_:N5f56844dc2e54f40a1dbe3a254a899fb"}, {"@id": "_:Nd6d7e4545f9c405dbc33d68be3f3d0c4"}], "http://schema.org/mainEntityOfPage": [{"@id": "https://pharos.nih.gov/ligands/Q8TW62QMB593"}], "http://schema.org/name": [{"@value": "KN-93"}], "http://schema.org/url": [{"@id": "https://pharos.nih.gov/ligands/Q8TW62QMB593"}]}, {"@id": "_:Ne8eea76a803e438db9a205069861007b", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Name"}], "http://schema.org/value": [{"@value": "KN-93"}]}, {"@id": "_:N5f56844dc2e54f40a1dbe3a254a899fb", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "PubChem"}], "http://schema.org/url": [{"@id": "https://pubchem.ncbi.nlm.nih.gov/compound/5312122"}], "http://schema.org/value": [{"@value": "5312122"}]}, {"@id": "_:Nd6d7e4545f9c405dbc33d68be3f3d0c4", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Guide to Pharmacology"}], "http://schema.org/url": [{"@id": "http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6002"}], "http://schema.org/value": [{"@value": "6002"}]}, {"@id": "https://pharos.nih.gov/targets/DNAAF2", "@type": ["http://schema.org/Protein"], "http://purl.org/dc/terms/conformsTo": [{"@id": "https://bioschemas.org/profiles/Protein/0.11-RELEASE"}], "http://schema.org/identifier": [{"@id": "_:N251941ee7113490185bbc76285113f0c"}, {"@id": "_:Nbc4e692ca57d4e7da0d4a6864f1c38f2"}], "http://schema.org/mainEntityOfPage": [{"@id": "https://pharos.nih.gov/targets/DNAAF2"}], "http://schema.org/name": [{"@value": "Protein kintoun"}], "http://schema.org/url": [{"@id": "https://pharos.nih.gov/targets/DNAAF2"}]}, {"@id": "_:N251941ee7113490185bbc76285113f0c", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Gene Symbol"}], "http://schema.org/value": [{"@value": "DNAAF2"}]}, {"@id": "_:Nbc4e692ca57d4e7da0d4a6864f1c38f2", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "UniProt ID"}], "http://schema.org/value": [{"@value": "Q9NVR5"}]}, {"@id": "https://pharos.nih.gov/targets/HAX1", "@type": ["http://schema.org/Protein"], "http://purl.org/dc/terms/conformsTo": [{"@id": "https://bioschemas.org/profiles/Protein/0.11-RELEASE"}], "http://schema.org/identifier": [{"@id": "_:N10abf1b8c42b40c98f8fa422959b1605"}, {"@id": "_:Nf63368ff8d0c441ba4fd878d4767901c"}], "http://schema.org/mainEntityOfPage": [{"@id": "https://pharos.nih.gov/targets/HAX1"}], "http://schema.org/name": [{"@value": "HCLS1-associated protein X-1"}], "http://schema.org/url": [{"@id": "https://pharos.nih.gov/targets/HAX1"}]}, {"@id": "_:N10abf1b8c42b40c98f8fa422959b1605", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "UniProt ID"}], "http://schema.org/value": [{"@value": "O00165"}]}, {"@id": "_:Nf63368ff8d0c441ba4fd878d4767901c", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Gene Symbol"}], "http://schema.org/value": [{"@value": "HAX1"}]}, {"@id": "https://pharos.nih.gov/ligands/4UXS9UGRZQTR", "@type": ["http://schema.org/ChemicalSubstance"], "http://purl.org/dc/terms/conformsTo": [{"@id": "https://bioschemas.org/profiles/ChemicalSubstance/0.4-RELEASE"}], "http://schema.org/chemicalComposition": [{"@value": "CN[C@@H]1C[C@H]2O[C@]([C@@H]1OC)(C)n1c3ccccc3c3c1c1n2c2ccccc2c1c1c3CNC1=O"}], "http://schema.org/identifier": [{"@id": "_:N7da3b639bf2648178ef1f798f3d29684"}, {"@id": "_:Na9d3646bdef7430d966a73178ed0cea5"}, {"@id": "_:N4ddfcfa083a4454b99165c41ba8daf2e"}, {"@id": "_:Ncdde620037404a8f8e0eadb8c3cbfad2"}], "http://schema.org/mainEntityOfPage": [{"@id": "https://pharos.nih.gov/ligands/4UXS9UGRZQTR"}], "http://schema.org/name": [{"@value": "staurosporine"}], "http://schema.org/url": [{"@id": "https://pharos.nih.gov/ligands/4UXS9UGRZQTR"}]}, {"@id": "_:N7da3b639bf2648178ef1f798f3d29684", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "PubChem"}], "http://schema.org/url": [{"@id": "https://pubchem.ncbi.nlm.nih.gov/compound/44259"}], "http://schema.org/value": [{"@value": "44259"}]}, {"@id": "_:Na9d3646bdef7430d966a73178ed0cea5", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "ChEMBL"}], "http://schema.org/url": [{"@id": "https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL388978/"}], "http://schema.org/value": [{"@value": "CHEMBL388978"}]}, {"@id": "_:N4ddfcfa083a4454b99165c41ba8daf2e", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Guide to Pharmacology"}], "http://schema.org/url": [{"@id": "http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=346"}], "http://schema.org/value": [{"@value": "346"}]}, {"@id": "_:Ncdde620037404a8f8e0eadb8c3cbfad2", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Name"}], "http://schema.org/value": [{"@value": "staurosporine"}]}, {"@id": "https://pharos.nih.gov/diseases/cocaine%20abuse", "@type": ["http://schema.org/MedicalCondition"], "http://schema.org/identifier": [{"@id": "_:Nde3bcad865d942138d1223d5cf714032"}], "http://schema.org/mainEntityOfPage": [{"@id": "https://pharos.nih.gov/diseases/cocaine%20abuse"}], "http://schema.org/name": [{"@value": "cocaine abuse"}], "http://schema.org/url": [{"@id": "https://pharos.nih.gov/diseases/cocaine%20abuse"}]}, {"@id": "_:Nde3bcad865d942138d1223d5cf714032", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "MONDO ID"}], "http://schema.org/value": [{"@value": "MONDO:0004456"}]}, {"@id": "_:N885150a234664767bf30b6dfa43b23d9", "@type": ["http://schema.org/Organization"], "http://schema.org/description": [{"@value": "Pharos is the web interface for data collected by the Illuminating the Druggable Genome initiative. Target, disease and ligand information are collected and displayed."}], "http://schema.org/logo": [{"@id": "https://pharos.nih.gov/assets/images/Pharos_Logo_Rd8.svg"}], "http://schema.org/name": [{"@value": "Pharos : Illuminating the Druggable Genome"}], "http://schema.org/potentialAction": [{"@id": "_:N4df9c666e3394495b30200352c335d13"}], "http://schema.org/sameAs": [{"@id": "https://www.youtube.com/c/DruggableGenomeIDG"}, {"@id": "https://twitter.com/idg_pharos"}], "http://schema.org/url": [{"@id": "https://pharos.nih.gov"}]}, {"@id": "_:N4df9c666e3394495b30200352c335d13", "@type": ["http://schema.org/SearchAction"], "http://schema.org/query": [{"@value": "required"}], "http://schema.org/target": [{"@id": "https://pharos.nih.gov/search?q={query}"}]}, {"@id": "https://pharos.nih.gov/targets/CAMK2A", "@type": ["http://schema.org/Protein"], "http://ogp.me/ns#description": [{"@value": "Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2018]"}], "http://ogp.me/ns#image": [{"@value": "assets/icons/icon-192px.png"}], "http://ogp.me/ns#image:secure_url": [{"@value": "assets/icons/icon-192px.png"}], "http://ogp.me/ns#image:type": [{"@value": "image/png"}], "http://ogp.me/ns#title": [{"@value": "Pharos: Calcium/calmodulin-dependent protein kinase type II subunit alpha (Tchem)"}], "http://ogp.me/ns#url": [{"@value": "https://pharos.nih.gov"}], "http://purl.org/dc/terms/conformsTo": [{"@id": "https://bioschemas.org/profiles/Protein/0.11-RELEASE"}], "http://schema.org/associatedDisease": [{"@id": "https://pharos.nih.gov/diseases/cocaine%20dependence"}, {"@id": "https://pharos.nih.gov/diseases/cocaine%20abuse"}, {"@id": "https://pharos.nih.gov/diseases/malignant%20ependymoma"}, {"@id": "https://pharos.nih.gov/diseases/Hyperalgesia"}, {"@id": "https://pharos.nih.gov/diseases/mast%20cell%20leukemia"}, {"@id": "https://pharos.nih.gov/diseases/Wilson%20disease"}, {"@id": "https://pharos.nih.gov/diseases/intellectual%20disability%2C%20autosomal%20dominant%2053"}, {"@id": "https://pharos.nih.gov/diseases/ovarian%20cancer"}, {"@id": "https://pharos.nih.gov/diseases/Hepatomegaly"}, {"@id": "https://pharos.nih.gov/diseases/Mental%20Depression"}], "http://schema.org/bioChemInteraction": [{"@id": "https://pharos.nih.gov/targets/ARMC1"}, {"@id": "https://pharos.nih.gov/targets/CAMK2G"}, {"@id": "https://pharos.nih.gov/targets/NUFIP1"}, {"@id": "https://pharos.nih.gov/targets/HAX1"}, {"@id": "https://pharos.nih.gov/ligands/midostaurin"}, {"@id": "https://pharos.nih.gov/ligands/AFCJ95Q3AR7F"}, {"@id": "https://pharos.nih.gov/targets/CDCA8"}, {"@id": "https://pharos.nih.gov/ligands/4UXS9UGRZQTR"}, {"@id": "https://pharos.nih.gov/targets/CAMK2D"}, {"@id": "https://pharos.nih.gov/ligands/Q8TW62QMB593"}, {"@id": "https://pharos.nih.gov/ligands/4UXPNBHU6CAL"}, {"@id": "https://pharos.nih.gov/targets/DNAAF2"}, {"@id": "https://pharos.nih.gov/targets/RRP7A"}, {"@id": "https://pharos.nih.gov/ligands/JRQZXU1XYFJW"}, {"@id": "https://pharos.nih.gov/targets/DGUOK"}, {"@id": "https://pharos.nih.gov/targets/CAMK2B"}, {"@id": "https://pharos.nih.gov/ligands/G3KAGHS4CG2M"}, {"@id": "https://pharos.nih.gov/ligands/JJKPSGPHHFRR"}], "http://schema.org/description": [{"@value": "Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2018]"}], "http://schema.org/hasBioChemEntityPart": [{"@id": "_:N126f8d7f1bda473086dc8574215afdd4"}, {"@id": "_:N3427721934d94e629718bf20c74587e5"}, {"@id": "_:Nf010b13e836a47a6a468f633a44a59e7"}, {"@id": "_:Nd1d109c149444d5b8e8f4048565018b0"}, {"@id": "_:N2e84cf52cc39438a9d267f589dc1aee9"}, {"@id": "_:N01ab8f3a30fb4c218dd4c91d8f0b586a"}, {"@id": "_:N387447620cd447139ca019d1cf994478"}, {"@id": "_:N6c759643b31b4175a25e749f4c03156a"}, {"@id": "_:Nae61f657e51843bf9f328a3ad5ec618b"}, {"@id": "_:N6783ed18a74b400ab772a898903c412c"}, {"@id": "_:N2b99069ca6634da1a74363f7094d676a"}, {"@id": "_:N26473722cfa246efacfc75368a4e8909"}, {"@id": "_:N0040479c68a948eb873c4f16a637bdd2"}, {"@id": "_:N97b93a728fd34449bfe89e4e74bd258a"}, {"@id": "_:Nfcfb3d5b26144aa8a48f232067ba949e"}, {"@id": "_:N396cd0f666104795adc8974033bbd9c4"}, {"@id": "_:N8b97c4042ccb4f14bf22f25d788a4c6f"}, {"@id": "_:N893f4643fb8147ffa40b4e447ff03b0b"}, {"@id": "_:N93e457ca348540fca24df0af56f190ca"}, {"@id": "_:N909a4de19c0043049ea9b8a7b266b3a2"}], "http://schema.org/hasBioPolymerSequence": [{"@value": "MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSGGKSGGNKKSDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH"}], "http://schema.org/hasMolecularFunction": [{"@id": "_:N449dc72608c3478591494169ee632436"}, {"@id": "_:N915628e597a543ce989e64191dfafcba"}, {"@id": "_:Nb11c343282004793a37bdd07644384e0"}, {"@id": "_:Nb35f17777d864c48aa0cb5837d0369a7"}, {"@id": "_:N6e563266ccab48289e2aba7ccb9a24da"}], "http://schema.org/identifier": [{"@id": "_:Nf8c663a117bc4ec9a8352b53fdf1d32a"}, {"@id": "_:N69e9eadee8df433baff9e94a24d7b332"}], "http://schema.org/isInvolvedInBiologicalProcess": [{"@id": "_:N98f68e1ec4dc4a368ddfc44032166ec0"}, {"@id": "_:Nb3d6879d37984adb879f3f8e3a6d61c2"}, {"@id": "_:N9f917ca9108e4d0b8c8b49a31ce20b13"}, {"@id": "_:N75439d51b5074e7d8638596b0d6c1ada"}, {"@id": "_:N79f2df6e2640418eaba1aa3a94ee7478"}], "http://schema.org/isLocatedInSubcellularLocation": [{"@id": "_:N2ec5c282d2a54e9b84e51dd3ddcf2d8c"}, {"@id": "_:N528eed2a75d645bab005d12b6b939c23"}, {"@id": "_:N7cca6454cd5447b185f2981a9ee2e23c"}, {"@id": "_:Nd4a675de427f45a7a5918fe6182f052b"}, {"@id": "_:Nbac42d96c3c543e08f27fbe6445c321c"}], "http://schema.org/mainEntityOfPage": [{"@id": "https://pharos.nih.gov/targets/CAMK2A"}], "http://schema.org/name": [{"@value": "Calcium/calmodulin-dependent protein kinase type II subunit alpha"}], "http://schema.org/url": [{"@id": "https://pharos.nih.gov/targets/CAMK2A"}], "https://dev.twitter.com/cards#description": [{"@value": "Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2018]"}]}, {"@id": "_:N126f8d7f1bda473086dc8574215afdd4", "@type": ["http://schema.org/BioChemEntity"], "http://schema.org/identifier": [{"@id": "_:N95cd15a7c83e4b648eb1a52e7d9c5115"}], "http://schema.org/mainEntityOfPage": [{"@id": "http://apps.pathwaycommons.org/pathways?uri=http%3A%2F%2Fpathwaycommons.org%2Fpc11%2FPathway_33e0b1dfe66b796d1f4b662240ec2a54"}], "http://schema.org/name": [{"@value": "Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram )"}]}, {"@id": "_:N95cd15a7c83e4b648eb1a52e7d9c5115", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Pathway Source"}], "http://schema.org/value": [{"@value": "PathwayCommons: inoh"}]}, {"@id": "_:N3427721934d94e629718bf20c74587e5", "@type": ["http://schema.org/BioChemEntity"], "http://schema.org/identifier": [{"@id": "_:N6b2a27d858c54f9bacf4dcb127a25fbf"}, {"@id": "_:Ne58ef3809ac4491fa696a11331ab40ff"}], "http://schema.org/mainEntityOfPage": [{"@id": "http://www.kegg.jp/kegg-bin/show_pathway?hsa04750"}], "http://schema.org/name": [{"@value": "Inflammatory mediator regulation of TRP channels"}]}, {"@id": "_:N6b2a27d858c54f9bacf4dcb127a25fbf", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Pathway Source"}], "http://schema.org/value": [{"@value": "KEGG"}]}, {"@id": "_:Ne58ef3809ac4491fa696a11331ab40ff", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Pathway ID"}], "http://schema.org/value": [{"@value": "path:hsa04750"}]}, {"@id": "_:Nf010b13e836a47a6a468f633a44a59e7", "@type": ["http://schema.org/BioChemEntity"], "http://schema.org/identifier": [{"@id": "_:Nb80616ae3d3e4f5999d22e0be843738b"}, {"@id": "_:N7e62c2766bf5440db71050205083a291"}], "http://schema.org/mainEntityOfPage": [{"@id": "http://www.wikipathways.org/instance/WP23_r105541"}], "http://schema.org/name": [{"@value": "B Cell Receptor Signaling Pathway"}]}, {"@id": "_:Nb80616ae3d3e4f5999d22e0be843738b", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Pathway ID"}], "http://schema.org/value": [{"@value": "WP23_r105541"}]}, {"@id": "_:N7e62c2766bf5440db71050205083a291", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Pathway Source"}], "http://schema.org/value": [{"@value": "WikiPathways"}]}, {"@id": "_:Nd1d109c149444d5b8e8f4048565018b0", "@type": ["http://schema.org/BioChemEntity"], "http://schema.org/identifier": [{"@id": "_:Nde99323f7ba042bb9018de76279929e3"}, {"@id": "_:N5833aa4eba734e5faaac02e108a33c91"}], "http://schema.org/mainEntityOfPage": [{"@id": "http://www.kegg.jp/kegg-bin/show_pathway?hsa04360"}], "http://schema.org/name": [{"@value": "Axon guidance"}]}, {"@id": "_:Nde99323f7ba042bb9018de76279929e3", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Pathway ID"}], "http://schema.org/value": [{"@value": "path:hsa04360"}]}, {"@id": "_:N5833aa4eba734e5faaac02e108a33c91", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Pathway Source"}], "http://schema.org/value": [{"@value": "KEGG"}]}, {"@id": "_:N2e84cf52cc39438a9d267f589dc1aee9", "@type": ["http://schema.org/BioChemEntity"], "http://schema.org/identifier": [{"@id": "_:Nc2a2f3772757405ab3e9f9dcff277e77"}, {"@id": "_:N5a1c7bbe6064429db46f88b9861756bb"}], "http://schema.org/mainEntityOfPage": [{"@id": "http://www.kegg.jp/kegg-bin/show_pathway?hsa04925"}], "http://schema.org/name": [{"@value": "Aldosterone synthesis and secretion"}]}, {"@id": "_:Nc2a2f3772757405ab3e9f9dcff277e77", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Pathway Source"}], "http://schema.org/value": [{"@value": "KEGG"}]}, {"@id": "_:N5a1c7bbe6064429db46f88b9861756bb", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Pathway ID"}], "http://schema.org/value": [{"@value": "path:hsa04925"}]}, {"@id": "_:N01ab8f3a30fb4c218dd4c91d8f0b586a", "@type": ["http://schema.org/BioChemEntity"], "http://schema.org/identifier": [{"@id": "_:N9f3cb33762c04efdb97d6c3e41807bc8"}], "http://schema.org/mainEntityOfPage": [{"@id": "http://apps.pathwaycommons.org/pathways?uri=http%3A%2F%2Fidentifiers.org%2Fpanther.pathway%2FP00037"}], "http://schema.org/name": [{"@value": "Ionotropic glutamate receptor pathway"}]}, {"@id": "_:N9f3cb33762c04efdb97d6c3e41807bc8", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Pathway Source"}], "http://schema.org/value": [{"@value": "PathwayCommons: panther"}]}, {"@id": "_:N387447620cd447139ca019d1cf994478", "@type": ["http://schema.org/BioChemEntity"], "http://schema.org/identifier": [{"@id": "_:N05b03a038e0148c99340f31b87694ac4"}], "http://schema.org/mainEntityOfPage": [{"@id": "http://apps.pathwaycommons.org/pathways?uri=http%3A%2F%2Fpathwaycommons.org%2Fpc11%2FPathway_01bb03155e5e2b060a0bce463e22bf30"}], "http://schema.org/name": [{"@value": "IFN-gamma pathway"}]}, {"@id": "_:N05b03a038e0148c99340f31b87694ac4", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Pathway Source"}], "http://schema.org/value": [{"@value": "PathwayCommons: pid"}]}, {"@id": "_:N6c759643b31b4175a25e749f4c03156a", "@type": ["http://schema.org/BioChemEntity"], "http://schema.org/identifier": [{"@id": "_:Nce4cd5283a154e448e14e9150b32d704"}], "http://schema.org/mainEntityOfPage": [{"@id": "http://apps.pathwaycommons.org/pathways?uri=http%3A%2F%2Fidentifiers.org%2Fpanther.pathway%2FP00031"}], "http://schema.org/name": [{"@value": "Inflammation mediated by chemokine and cytokine signaling pathway"}]}, {"@id": "_:Nce4cd5283a154e448e14e9150b32d704", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Pathway Source"}], "http://schema.org/value": [{"@value": "PathwayCommons: panther"}]}, {"@id": "_:Nae61f657e51843bf9f328a3ad5ec618b", "@type": ["http://schema.org/BioChemEntity"], "http://schema.org/identifier": [{"@id": "_:Nf71663e13c3b493dbf07c49cd7ce40bd"}, {"@id": "_:Nbe6e6bded7f64b06823097c41bbfcab4"}], "http://schema.org/mainEntityOfPage": [{"@id": "http://www.wikipathways.org/instance/WP3298_r106153"}], "http://schema.org/name": [{"@value": "Melatonin metabolism and effects"}]}, {"@id": "_:Nf71663e13c3b493dbf07c49cd7ce40bd", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Pathway ID"}], "http://schema.org/value": [{"@value": "WP3298_r106153"}]}, {"@id": "_:Nbe6e6bded7f64b06823097c41bbfcab4", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Pathway Source"}], "http://schema.org/value": [{"@value": "WikiPathways"}]}, {"@id": "_:N6783ed18a74b400ab772a898903c412c", "@type": ["http://schema.org/BioChemEntity"], "http://schema.org/identifier": [{"@id": "_:N5f4b1fc036684ea9967f75f37b5a9b8f"}, {"@id": "_:N88104a4972d34595b25d10075cc9a786"}], "http://schema.org/mainEntityOfPage": [{"@id": "http://www.wikipathways.org/instance/WP536_r105547"}], "http://schema.org/name": [{"@value": "Calcium Regulation in the Cardiac Cell"}]}, {"@id": "_:N5f4b1fc036684ea9967f75f37b5a9b8f", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Pathway Source"}], "http://schema.org/value": [{"@value": "WikiPathways"}]}, {"@id": "_:N88104a4972d34595b25d10075cc9a786", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Pathway ID"}], "http://schema.org/value": [{"@value": "WP536_r105547"}]}, {"@id": "_:N2b99069ca6634da1a74363f7094d676a", "@type": ["http://schema.org/BioChemEntity"], "http://schema.org/identifier": [{"@id": "_:N3226662777734b6aadd32df07f865287"}, {"@id": "_:N9372c92fea084c58b3a4b82bb88f9de4"}], "http://schema.org/mainEntityOfPage": [{"@id": "https://idg.reactome.org/PathwayBrowser/#/R-HSA-9609736&FLG=CAMK2A"}], "http://schema.org/name": [{"@value": "Assembly and cell surface presentation of NMDA receptors"}]}, {"@id": "_:N3226662777734b6aadd32df07f865287", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Pathway ID"}], "http://schema.org/value": [{"@value": "R-HSA-9609736"}]}, {"@id": "_:N9372c92fea084c58b3a4b82bb88f9de4", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Pathway Source"}], "http://schema.org/value": [{"@value": "Reactome"}]}, {"@id": "_:N26473722cfa246efacfc75368a4e8909", "@type": ["http://schema.org/BioChemEntity"], "http://schema.org/identifier": [{"@id": "_:N761246595343485dbfccfd0f5f62130e"}, {"@id": "_:Nafa265f9c3124f398a76edec34c735a4"}], "http://schema.org/mainEntityOfPage": [{"@id": "https://idg.reactome.org/PathwayBrowser/#/R-HSA-442755&FLG=CAMK2A"}], "http://schema.org/name": [{"@value": "Activation of NMDA receptors and postsynaptic events"}]}, {"@id": "_:N761246595343485dbfccfd0f5f62130e", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Pathway Source"}], "http://schema.org/value": [{"@value": "Reactome"}]}, {"@id": "_:Nafa265f9c3124f398a76edec34c735a4", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Pathway ID"}], "http://schema.org/value": [{"@value": "R-HSA-442755"}]}, {"@id": "_:N0040479c68a948eb873c4f16a637bdd2", "@type": ["http://schema.org/BioChemEntity"], "http://schema.org/identifier": [{"@id": "_:N80a39eca85e64b31964651de02566790"}, {"@id": "_:N7f95b4287d5043368a3c9b03c53a0b9f"}], "http://schema.org/mainEntityOfPage": [{"@id": "http://www.kegg.jp/kegg-bin/show_pathway?hsa04921"}], "http://schema.org/name": [{"@value": "Oxytocin signaling pathway"}]}, {"@id": "_:N80a39eca85e64b31964651de02566790", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Pathway ID"}], "http://schema.org/value": [{"@value": "path:hsa04921"}]}, {"@id": "_:N7f95b4287d5043368a3c9b03c53a0b9f", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Pathway Source"}], "http://schema.org/value": [{"@value": "KEGG"}]}, {"@id": "_:N97b93a728fd34449bfe89e4e74bd258a", "@type": ["http://schema.org/BioChemEntity"], "http://schema.org/identifier": [{"@id": "_:N3fb5dd9c095e41048f78b97b06caad87"}], "http://schema.org/mainEntityOfPage": [{"@id": "http://apps.pathwaycommons.org/pathways?uri=http%3A%2F%2Fpathwaycommons.org%2Fpc11%2FPathway_41362e44a39a2446580e8a2491eb25f7"}], "http://schema.org/name": [{"@value": "VEGF signaling pathway ( VEGF signaling pathway )"}]}, {"@id": "_:N3fb5dd9c095e41048f78b97b06caad87", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Pathway Source"}], "http://schema.org/value": [{"@value": "PathwayCommons: inoh"}]}, {"@id": "_:Nfcfb3d5b26144aa8a48f232067ba949e", "@type": ["http://schema.org/BioChemEntity"], "http://schema.org/identifier": [{"@id": "_:N91b8659fbf6f4778ab1a9b175850d5b5"}, {"@id": "_:Nd9dfb60a40fe4b6eb5789df8ff63be96"}], "http://schema.org/mainEntityOfPage": [{"@id": "https://idg.reactome.org/PathwayBrowser/#/R-HSA-3858494&FLG=CAMK2A"}], "http://schema.org/name": [{"@value": "Beta-catenin independent WNT signaling"}]}, {"@id": "_:N91b8659fbf6f4778ab1a9b175850d5b5", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Pathway Source"}], "http://schema.org/value": [{"@value": "Reactome"}]}, {"@id": "_:Nd9dfb60a40fe4b6eb5789df8ff63be96", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Pathway ID"}], "http://schema.org/value": [{"@value": "R-HSA-3858494"}]}, {"@id": "_:N396cd0f666104795adc8974033bbd9c4", "@type": ["http://schema.org/BioChemEntity"], "http://schema.org/identifier": [{"@id": "_:N1d4a5adb1283448fbabf1d7ac57dee59"}, {"@id": "_:Nb35f3720b5704aac97fea88d08256af9"}], "http://schema.org/mainEntityOfPage": [{"@id": "http://www.kegg.jp/kegg-bin/show_pathway?hsa04971"}], "http://schema.org/name": [{"@value": "Gastric acid secretion"}]}, {"@id": "_:N1d4a5adb1283448fbabf1d7ac57dee59", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Pathway Source"}], "http://schema.org/value": [{"@value": "KEGG"}]}, {"@id": "_:Nb35f3720b5704aac97fea88d08256af9", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Pathway ID"}], "http://schema.org/value": [{"@value": "path:hsa04971"}]}, {"@id": "_:N8b97c4042ccb4f14bf22f25d788a4c6f", "@type": ["http://schema.org/BioChemEntity"], "http://schema.org/identifier": [{"@id": "_:N5ad76c21d3c94b3e9a1ef0dd19d5f828"}, {"@id": "_:N4e4cadcc287948a3844d838c6e549f5f"}], "http://schema.org/mainEntityOfPage": [{"@id": "https://idg.reactome.org/PathwayBrowser/#/R-HSA-111996&FLG=CAMK2A"}], "http://schema.org/name": [{"@value": "Ca-dependent events"}]}, {"@id": "_:N5ad76c21d3c94b3e9a1ef0dd19d5f828", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Pathway ID"}], "http://schema.org/value": [{"@value": "R-HSA-111996"}]}, {"@id": "_:N4e4cadcc287948a3844d838c6e549f5f", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Pathway Source"}], "http://schema.org/value": [{"@value": "Reactome"}]}, {"@id": "_:N893f4643fb8147ffa40b4e447ff03b0b", "@type": ["http://schema.org/BioChemEntity"], "http://schema.org/identifier": [{"@id": "_:Nf4ce1fd846e4447dac458582a6b899a8"}, {"@id": "_:Nb5d270f7de134bc7b6aafd5460c29d40"}], "http://schema.org/mainEntityOfPage": [{"@id": "https://idg.reactome.org/PathwayBrowser/#/R-HSA-442742&FLG=CAMK2A"}], "http://schema.org/name": [{"@value": "CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling"}]}, {"@id": "_:Nf4ce1fd846e4447dac458582a6b899a8", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Pathway Source"}], "http://schema.org/value": [{"@value": "Reactome"}]}, {"@id": "_:Nb5d270f7de134bc7b6aafd5460c29d40", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Pathway ID"}], "http://schema.org/value": [{"@value": "R-HSA-442742"}]}, {"@id": "_:N93e457ca348540fca24df0af56f190ca", "@type": ["http://schema.org/BioChemEntity"], "http://schema.org/identifier": [{"@id": "_:N5be5327df4784355b241ee8c8dd2a022"}, {"@id": "_:Nd6a2706babc54be3bd48240e944a4fbf"}], "http://schema.org/mainEntityOfPage": [{"@id": "http://www.wikipathways.org/instance/WP3584_r105641"}], "http://schema.org/name": [{"@value": "MECP2 and Associated Rett Syndrome"}]}, {"@id": "_:N5be5327df4784355b241ee8c8dd2a022", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Pathway ID"}], "http://schema.org/value": [{"@value": "WP3584_r105641"}]}, {"@id": "_:Nd6a2706babc54be3bd48240e944a4fbf", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Pathway Source"}], "http://schema.org/value": [{"@value": "WikiPathways"}]}, {"@id": "_:N909a4de19c0043049ea9b8a7b266b3a2", "@type": ["http://schema.org/BioChemEntity"], "http://schema.org/identifier": [{"@id": "_:N2d0e450bc11d4c1bb26db2259b3e23a7"}, {"@id": "_:N5b62ee5602d24de39dfa46553ad944a5"}], "http://schema.org/mainEntityOfPage": [{"@id": "http://www.wikipathways.org/instance/WP437_r105574"}], "http://schema.org/name": [{"@value": "EGF/EGFR Signaling Pathway"}]}, {"@id": "_:N2d0e450bc11d4c1bb26db2259b3e23a7", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Pathway Source"}], "http://schema.org/value": [{"@value": "WikiPathways"}]}, {"@id": "_:N5b62ee5602d24de39dfa46553ad944a5", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Pathway ID"}], "http://schema.org/value": [{"@value": "WP437_r105574"}]}, {"@id": "_:Nf8c663a117bc4ec9a8352b53fdf1d32a", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "UniProt ID"}], "http://schema.org/value": [{"@value": "Q9UQM7"}]}, {"@id": "_:N69e9eadee8df433baff9e94a24d7b332", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Gene Symbol"}], "http://schema.org/value": [{"@value": "CAMK2A"}]}, {"@id": "_:N2ec5c282d2a54e9b84e51dd3ddcf2d8c", "@type": ["http://schema.org/DefinedTerm"], "http://schema.org/inDefinedTermSet": [{"@id": "_:N6306684d124045d9b6bc2d711193bfe3"}], "http://schema.org/termCode": [{"@value": "nucleus"}]}, {"@id": "_:N6306684d124045d9b6bc2d711193bfe3", "@type": ["http://schema.org/DefinedTermSet"], "http://schema.org/maintainer": [{"@id": "_:N85afe118c91f4ce08041c7fe495a0d5c"}], "http://schema.org/name": [{"@value": "GO Component"}]}, {"@id": "_:N85afe118c91f4ce08041c7fe495a0d5c", "@type": ["http://schema.org/Organization"], "http://schema.org/name": [{"@value": "Gene Ontology"}], "http://schema.org/url": [{"@id": "http://geneontology.org/"}]}, {"@id": "_:N528eed2a75d645bab005d12b6b939c23", "@type": ["http://schema.org/DefinedTerm"], "http://schema.org/inDefinedTermSet": [{"@id": "_:N1863b12d195449d79456bec1af7dcd0d"}], "http://schema.org/termCode": [{"@value": "calcium- and calmodulin-dependent protein kinase complex"}]}, {"@id": "_:N1863b12d195449d79456bec1af7dcd0d", "@type": ["http://schema.org/DefinedTermSet"], "http://schema.org/maintainer": [{"@id": "_:N204be94ccaae4826a78f346421568314"}], "http://schema.org/name": [{"@value": "GO Component"}]}, {"@id": "_:N204be94ccaae4826a78f346421568314", "@type": ["http://schema.org/Organization"], "http://schema.org/name": [{"@value": "Gene Ontology"}], "http://schema.org/url": [{"@id": "http://geneontology.org/"}]}, {"@id": "_:N7cca6454cd5447b185f2981a9ee2e23c", "@type": ["http://schema.org/DefinedTerm"], "http://schema.org/inDefinedTermSet": [{"@id": "_:N39ece90f179d44aa9d75b14855e860b9"}], "http://schema.org/termCode": [{"@value": "neuron projection"}]}, {"@id": "_:N39ece90f179d44aa9d75b14855e860b9", "@type": ["http://schema.org/DefinedTermSet"], "http://schema.org/maintainer": [{"@id": "_:Ndbd48d99f38a41478bd64f9745145fbe"}], "http://schema.org/name": [{"@value": "GO Component"}]}, {"@id": "_:Ndbd48d99f38a41478bd64f9745145fbe", "@type": ["http://schema.org/Organization"], "http://schema.org/name": [{"@value": "Gene Ontology"}], "http://schema.org/url": [{"@id": "http://geneontology.org/"}]}, {"@id": "_:Nd4a675de427f45a7a5918fe6182f052b", "@type": ["http://schema.org/DefinedTerm"], "http://schema.org/inDefinedTermSet": [{"@id": "_:N809874dd160a492aab12d09431269def"}], "http://schema.org/termCode": [{"@value": "cytoplasm"}]}, {"@id": "_:N809874dd160a492aab12d09431269def", "@type": ["http://schema.org/DefinedTermSet"], "http://schema.org/maintainer": [{"@id": "_:Nd91c13cf91db4828b721ad0edb470113"}], "http://schema.org/name": [{"@value": "GO Component"}]}, {"@id": "_:Nd91c13cf91db4828b721ad0edb470113", "@type": ["http://schema.org/Organization"], "http://schema.org/name": [{"@value": "Gene Ontology"}], "http://schema.org/url": [{"@id": "http://geneontology.org/"}]}, {"@id": "_:Nbac42d96c3c543e08f27fbe6445c321c", "@type": ["http://schema.org/DefinedTerm"], "http://schema.org/inDefinedTermSet": [{"@id": "_:Na9aedd1eb5f645a49e26f0c67a10627b"}], "http://schema.org/termCode": [{"@value": "dendritic spine"}]}, {"@id": "_:Na9aedd1eb5f645a49e26f0c67a10627b", "@type": ["http://schema.org/DefinedTermSet"], "http://schema.org/maintainer": [{"@id": "_:N4acc3d2cf5a14919b8396e13f476702b"}], "http://schema.org/name": [{"@value": "GO Component"}]}, {"@id": "_:N4acc3d2cf5a14919b8396e13f476702b", "@type": ["http://schema.org/Organization"], "http://schema.org/name": [{"@value": "Gene Ontology"}], "http://schema.org/url": [{"@id": "http://geneontology.org/"}]}, {"@id": "_:N98f68e1ec4dc4a368ddfc44032166ec0", "@type": ["http://schema.org/DefinedTerm"], "http://schema.org/inDefinedTermSet": [{"@id": "_:N367e20847b7d443188e711450037030a"}], "http://schema.org/termCode": [{"@value": "protein phosphorylation"}]}, {"@id": "_:N367e20847b7d443188e711450037030a", "@type": ["http://schema.org/DefinedTermSet"], "http://schema.org/maintainer": [{"@id": "_:N470e2cdd016a4d8ab167cd1361970309"}], "http://schema.org/name": [{"@value": "GO Process"}]}, {"@id": "_:N470e2cdd016a4d8ab167cd1361970309", "@type": ["http://schema.org/Organization"], "http://schema.org/name": [{"@value": "Gene Ontology"}], "http://schema.org/url": [{"@id": "http://geneontology.org/"}]}, {"@id": "_:Nb3d6879d37984adb879f3f8e3a6d61c2", "@type": ["http://schema.org/DefinedTerm"], "http://schema.org/inDefinedTermSet": [{"@id": "_:Ndcc1c93cdbb642b4a343541d7001b22e"}], "http://schema.org/termCode": [{"@value": "positive regulation of NF-kappaB transcription factor activity"}]}, {"@id": "_:Ndcc1c93cdbb642b4a343541d7001b22e", "@type": ["http://schema.org/DefinedTermSet"], "http://schema.org/maintainer": [{"@id": "_:Nf182387db5384e0d83397fc5cc8c3ef8"}], "http://schema.org/name": [{"@value": "GO Process"}]}, {"@id": "_:Nf182387db5384e0d83397fc5cc8c3ef8", "@type": ["http://schema.org/Organization"], "http://schema.org/name": [{"@value": "Gene Ontology"}], "http://schema.org/url": [{"@id": "http://geneontology.org/"}]}, {"@id": "_:N9f917ca9108e4d0b8c8b49a31ce20b13", "@type": ["http://schema.org/DefinedTerm"], "http://schema.org/inDefinedTermSet": [{"@id": "_:N4a2a8d74cb854fdf979a9daeb9138f82"}], "http://schema.org/termCode": [{"@value": "angiotensin-activated signaling pathway"}]}, {"@id": "_:N4a2a8d74cb854fdf979a9daeb9138f82", "@type": ["http://schema.org/DefinedTermSet"], "http://schema.org/maintainer": [{"@id": "_:Ndf5f5d81412d4a5499be8d39dab73a87"}], "http://schema.org/name": [{"@value": "GO Process"}]}, {"@id": "_:Ndf5f5d81412d4a5499be8d39dab73a87", "@type": ["http://schema.org/Organization"], "http://schema.org/name": [{"@value": "Gene Ontology"}], "http://schema.org/url": [{"@id": "http://geneontology.org/"}]}, {"@id": "_:N75439d51b5074e7d8638596b0d6c1ada", "@type": ["http://schema.org/DefinedTerm"], "http://schema.org/inDefinedTermSet": [{"@id": "_:Na3cf0ccfd66144cfab318768f63e6aee"}], "http://schema.org/termCode": [{"@value": "dendritic spine development"}]}, {"@id": "_:Na3cf0ccfd66144cfab318768f63e6aee", "@type": ["http://schema.org/DefinedTermSet"], "http://schema.org/maintainer": [{"@id": "_:N2879995bb2ff4120947e457c2920ac57"}], "http://schema.org/name": [{"@value": "GO Process"}]}, {"@id": "_:N2879995bb2ff4120947e457c2920ac57", "@type": ["http://schema.org/Organization"], "http://schema.org/name": [{"@value": "Gene Ontology"}], "http://schema.org/url": [{"@id": "http://geneontology.org/"}]}, {"@id": "_:N79f2df6e2640418eaba1aa3a94ee7478", "@type": ["http://schema.org/DefinedTerm"], "http://schema.org/inDefinedTermSet": [{"@id": "_:N2e00bf63474746d98bce021bad0a9a1d"}], "http://schema.org/termCode": [{"@value": "peptidyl-threonine autophosphorylation"}]}, {"@id": "_:N2e00bf63474746d98bce021bad0a9a1d", "@type": ["http://schema.org/DefinedTermSet"], "http://schema.org/maintainer": [{"@id": "_:N67a7e5f7d60b4fc6ba655c8d08f7bacb"}], "http://schema.org/name": [{"@value": "GO Process"}]}, {"@id": "_:N67a7e5f7d60b4fc6ba655c8d08f7bacb", "@type": ["http://schema.org/Organization"], "http://schema.org/name": [{"@value": "Gene Ontology"}], "http://schema.org/url": [{"@id": "http://geneontology.org/"}]}, {"@id": "_:N449dc72608c3478591494169ee632436", "@type": ["http://schema.org/DefinedTerm"], "http://schema.org/inDefinedTermSet": [{"@id": "_:N8f1adc0c5b784f56bb02687f21b54067"}], "http://schema.org/termCode": [{"@value": "identical protein binding"}]}, {"@id": "_:N8f1adc0c5b784f56bb02687f21b54067", "@type": ["http://schema.org/DefinedTermSet"], "http://schema.org/maintainer": [{"@id": "_:N33a6507b9a834705b32f5f4b3a6045f1"}], "http://schema.org/name": [{"@value": "GO Function"}]}, {"@id": "_:N33a6507b9a834705b32f5f4b3a6045f1", "@type": ["http://schema.org/Organization"], "http://schema.org/name": [{"@value": "Gene Ontology"}], "http://schema.org/url": [{"@id": "http://geneontology.org/"}]}, {"@id": "_:N915628e597a543ce989e64191dfafcba", "@type": ["http://schema.org/DefinedTerm"], "http://schema.org/inDefinedTermSet": [{"@id": "_:N675cd88121334410b651001f4e3026e0"}], "http://schema.org/termCode": [{"@value": "protein serine/threonine kinase activity"}]}, {"@id": "_:N675cd88121334410b651001f4e3026e0", "@type": ["http://schema.org/DefinedTermSet"], "http://schema.org/maintainer": [{"@id": "_:N00a50364695840ff97c6d3e7375a91d1"}], "http://schema.org/name": [{"@value": "GO Function"}]}, {"@id": "_:N00a50364695840ff97c6d3e7375a91d1", "@type": ["http://schema.org/Organization"], "http://schema.org/name": [{"@value": "Gene Ontology"}], "http://schema.org/url": [{"@id": "http://geneontology.org/"}]}, {"@id": "_:Nb11c343282004793a37bdd07644384e0", "@type": ["http://schema.org/DefinedTerm"], "http://schema.org/inDefinedTermSet": [{"@id": "_:N2418b4232b1e4330967a06bb99745f2c"}], "http://schema.org/termCode": [{"@value": "protein homodimerization activity"}]}, {"@id": "_:N2418b4232b1e4330967a06bb99745f2c", "@type": ["http://schema.org/DefinedTermSet"], "http://schema.org/maintainer": [{"@id": "_:Nb53d85a9adb54810b00e333f8427de77"}], "http://schema.org/name": [{"@value": "GO Function"}]}, {"@id": "_:Nb53d85a9adb54810b00e333f8427de77", "@type": ["http://schema.org/Organization"], "http://schema.org/name": [{"@value": "Gene Ontology"}], "http://schema.org/url": [{"@id": "http://geneontology.org/"}]}, {"@id": "_:Nb35f17777d864c48aa0cb5837d0369a7", "@type": ["http://schema.org/DefinedTerm"], "http://schema.org/inDefinedTermSet": [{"@id": "_:N73fa2e18f6e84461b24c3426266b284e"}], "http://schema.org/termCode": [{"@value": "calmodulin binding"}]}, {"@id": "_:N73fa2e18f6e84461b24c3426266b284e", "@type": ["http://schema.org/DefinedTermSet"], "http://schema.org/maintainer": [{"@id": "_:Nc05e53706be74a12a574b900d1e25c9c"}], "http://schema.org/name": [{"@value": "GO Function"}]}, {"@id": "_:Nc05e53706be74a12a574b900d1e25c9c", "@type": ["http://schema.org/Organization"], "http://schema.org/name": [{"@value": "Gene Ontology"}], "http://schema.org/url": [{"@id": "http://geneontology.org/"}]}, {"@id": "_:N6e563266ccab48289e2aba7ccb9a24da", "@type": ["http://schema.org/DefinedTerm"], "http://schema.org/inDefinedTermSet": [{"@id": "_:N671cdb7bce1347f9bf584270f5f3bfbf"}], "http://schema.org/termCode": [{"@value": "kinase activity"}]}, {"@id": "_:N671cdb7bce1347f9bf584270f5f3bfbf", "@type": ["http://schema.org/DefinedTermSet"], "http://schema.org/maintainer": [{"@id": "_:Ndbb1f3e682a34f55adaaa024134220af"}], "http://schema.org/name": [{"@value": "GO Function"}]}, {"@id": "_:Ndbb1f3e682a34f55adaaa024134220af", "@type": ["http://schema.org/Organization"], "http://schema.org/name": [{"@value": "Gene Ontology"}], "http://schema.org/url": [{"@id": "http://geneontology.org/"}]}, {"@id": "https://pharos.nih.gov/targets/NUFIP1", "@type": ["http://schema.org/Protein"], "http://purl.org/dc/terms/conformsTo": [{"@id": "https://bioschemas.org/profiles/Protein/0.11-RELEASE"}], "http://schema.org/identifier": [{"@id": "_:N57eca242bc95499dbafc388eb4506d04"}, {"@id": "_:N896ab1b66fc64b92987025e339002d96"}], "http://schema.org/mainEntityOfPage": [{"@id": "https://pharos.nih.gov/targets/NUFIP1"}], "http://schema.org/name": [{"@value": "Nuclear fragile X mental retardation-interacting protein 1"}], "http://schema.org/url": [{"@id": "https://pharos.nih.gov/targets/NUFIP1"}]}, {"@id": "_:N57eca242bc95499dbafc388eb4506d04", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Gene Symbol"}], "http://schema.org/value": [{"@value": "NUFIP1"}]}, {"@id": "_:N896ab1b66fc64b92987025e339002d96", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "UniProt ID"}], "http://schema.org/value": [{"@value": "Q9UHK0"}]}, {"@id": "https://pharos.nih.gov/diseases/mast%20cell%20leukemia", "@type": ["http://schema.org/MedicalCondition"], "http://schema.org/identifier": [{"@id": "_:N79f7825888f443fa876d71ae011ec1da"}], "http://schema.org/mainEntityOfPage": [{"@id": "https://pharos.nih.gov/diseases/mast%20cell%20leukemia"}], "http://schema.org/name": [{"@value": "mast cell leukemia"}], "http://schema.org/url": [{"@id": "https://pharos.nih.gov/diseases/mast%20cell%20leukemia"}]}, {"@id": "_:N79f7825888f443fa876d71ae011ec1da", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "MONDO ID"}], "http://schema.org/value": [{"@value": "MONDO:0020334"}]}, {"@id": "https://pharos.nih.gov/targets/DGUOK", "@type": ["http://schema.org/Protein"], "http://purl.org/dc/terms/conformsTo": [{"@id": "https://bioschemas.org/profiles/Protein/0.11-RELEASE"}], "http://schema.org/identifier": [{"@id": "_:N8e1e63d7cce9498ebc8c663660f487e4"}, {"@id": "_:N04ec0de888004760ba042008cae5185f"}], "http://schema.org/mainEntityOfPage": [{"@id": "https://pharos.nih.gov/targets/DGUOK"}], "http://schema.org/name": [{"@value": "Deoxyguanosine kinase, mitochondrial"}], "http://schema.org/url": [{"@id": "https://pharos.nih.gov/targets/DGUOK"}]}, {"@id": "_:N8e1e63d7cce9498ebc8c663660f487e4", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "UniProt ID"}], "http://schema.org/value": [{"@value": "Q16854"}]}, {"@id": "_:N04ec0de888004760ba042008cae5185f", "@type": ["http://schema.org/PropertyValue"], "http://schema.org/name": [{"@value": "Gene Symbol"}], "http://schema.org/value": [{"@value": "DGUOK"}]}], "@id": "https://pharos.nih.gov/targets/CAMK2A#html"}]